Her clinical and clinical research focus has been paediatric inflammatory bowel disease. She is currently Principal Investigator of the Canadian Children IBD network: a joint partnership of CIHR and the CH.I.L.D. Foundation, involving 12 paediatric IBD centers across Canada. Within the Toronto SickKids IBD program, and as paediatric GI fellowship training program director (1998-2003) and GI Division Head (2008-2015), Dr. Griffiths has mentored and trained many paediatric gastroenterologists, now clinician investigators engaged in IBD clinical care and research nationally and internationally. Together with many of them, she has co-authored over 300 peer-reviewed manuscripts. Her contributions have been recognized with the 2019 Shwachman award of the North American Society for Paediatric Gastroenterology Hepatology and Nutrition and a 2019 American Association of Gastroenterology Research Mentor Award.