Dr. Rothman has been involved in research on immunity and pathogenesis of viral diseases in humans for over 25 years. A major focus of his research has been defining the virological and immunological events in acute dengue virus infection and their relationship to the development of the viral hemorrhagic fever syndrome. Dr. Rothman has long-standing collaborations with colleagues at the University of Massachusetts, Walter Reed Army Institute of Research, and internationally in Thailand, Europe, and Latin America. His current studies involve both clinical and basic research studies on pathogenesis and immunity of emerging and re-emerging viral infections. Dr. Rothman has served on advisory committees for the National Institutes of Health and the World Health Organization.