Alison Heggie - Newcastle University

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Discovery of Drug–omics Associations in Type 2 Diabetes with Generative Deep-Learning Models

Rosa Lundbye Allesøe,Agnete Troen Lundgaard,Ricardo Hernández Medina,Alejandro Aguayo-Orozco,Joachim Johansen,Jakob Nybo Nissen,Caroline Brorsson,Gianluca Mazzoni,Lili Niu,Jorge Hernansanz Biel,Cristina Leal Rodríguez,Valentas Brasas,Henry Webel,Michael Eriksen Benros,Anders Gorm Pedersen,Piotr Jaroslaw Chmura,Ulrik Plesner Jacobsen,Andrea Mari,Robert Koivula,Anubha Mahajan,Ana Vinuela,Juan Fernandez Tajes,Sapna Sharma,Mark Haid,Mun-Gwan Hong,Petra B. Musholt,Federico De Masi,Josef Vogt,Helle Krogh Pedersen,Valborg Gudmundsdottir,Angus Jones,Gwen Kennedy,Jimmy Bell,E. Louise Thomas,Gary Frost,Henrik Thomsen,Elizaveta Hansen,Tue Haldor Hansen,Henrik Vestergaard,Mirthe Muilwijk,Marieke T. Blom,Leen M. ‘t Hart,Francois Pattou,Violeta Raverdy,Soren Brage,Tarja Kokkola,Alison Heggie,Donna McEvoy,Miranda Mourby,Jane Kaye,Andrew Hattersley,Timothy McDonald,Martin Ridderstråle,Mark Walker,Ian Forgie,Giuseppe N. Giordano,Imre Pavo,Hartmut Ruetten,Oluf Pedersen,Torben Hansen,Emmanouil Dermitzakis,Paul W. Franks,Jochen M. Schwenk,Jerzy Adamski,Mark I. McCarthy,Ewan Pearson,Karina Banasik,Simon Rasmussen,Søren Brunak,Philippe Froguel

Nature biotechnology（2023）

引用10浏览0WOSNATURE引用

Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models (vol 41, pg 399, 2023)

Rosa Lundbye Allesoe,Agnete Troen Lundgaard,Ricardo Hernandez Medina,Alejandro Aguayo-Orozco,Joachim Johansen,Jakob Nybo Nissen,Caroline Brorsson,Gianluca Mazzoni,Lili Niu,Jorge Hernansanz Biel,Cristina Leal Rodriguez,Valentas Brasas,Henry Webel,Michael Eriksen Benros,Anders Gorm Pedersen,Piotr Jaroslaw Chmura,Ulrik Plesner Jacobsen,Andrea Mari,Robert Koivula,Anubha Mahajan,Ana Vinuela,Juan Fernandez Tajes,Sapna Sharma,Mark Haid,Mun-Gwan B. Hong,Petra Musholt,Federico De Masi,Josef Vogt,Helle Krogh Pedersen,Valborg Gudmundsdottir,Angus Jones,Gwen Kennedy,Jimmy Bell,E. Louise Thomas,Gary Frost,Henrik Thomsen,Elizaveta Hansen,Tue Haldor Hansen,Henrik Vestergaard,Mirthe T. Muilwijk,Marieke M. Blom,Leen 't Hart,Francois Pattou,Violeta Raverdy,Soren Brage,Tarja Kokkola,Alison Heggie,Donna McEvoy,Miranda Mourby,Jane Kaye,Andrew Hattersley,Timothy McDonald,Martin Ridderstrale,Mark Walker,Ian N. Forgie,Giuseppe Giordano,Imre Pavo,Hartmut Ruetten,Oluf Pedersen,Torben Hansen,Emmanouil W. Dermitzakis,Paul M. Franks,Jochen Schwenk,Jerzy I. Adamski,Mark McCarthy,Ewan Pearson,Karina Banasik,Simon Rasmussen,Soren Brunak

NATURE BIOTECHNOLOGYno. 7 (2023): 1026-1026

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Four Groups of Type 2 Diabetes Contribute to the Etiological and Clinical Heterogeneity in Newly Diagnosed Individuals: an IMI DIRECT Study

Agata Wesolowska‐Andersen, Brorsson CA,R Bizzotto,A Mari,A Tura,R Koivula,A Mahajan,A Vinuela, Tajes JF,S Sharma,M Haid,C Prehn,A Artati, Hong MG, Musholt PB,A Kurbasic,De Masi F,K Tsirigos, Pedersen HK,V Gudmundsdottir,Thomas CE,K Banasik,C Jennison,A Jones,G Kennedy,J Bell,L Thomas,G Frost, Helene B. Thomsen,K Allin, Hansen TH,H Vestergaard,T Hansen,F Rutters,P Elders,Leen t’Hart,A Bonnefond,M Canouil,S Brage,T Kokkola,A Heggie,D McEvoy,A Hattersley,T McDonald,H Teare,M Ridderstrale,M Walker,I Forgie, Giordano GN,P Froguel,I Pavo,H Ruetten,O Pedersen,E Dermitzakis, Franks PW, Schwenk JM,J Adamski,E Pearson, McCarthy MI,S Brunak, ID Consortium

Yearbook of pediatric endocrinology（2022）

引用35浏览0引用

Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

Naeimeh Atabaki-Pasdar,Mattias Ohlsson,Ana Vinuela,Francesca Frau,Hugo Pomares-Millan,Mark Haid,Angus G. Jones,E. Louise Thomas,Robert W. Koivula,Azra Kurbasic,Pascal M. Mutie,Hugo Fitipaldi,Juan Fernandez,Adem Y. Dawed,Giuseppe N. Giordano,Ian M. Forgie,Timothy J. McDonald,Femke Rutters,Henna Cederberg,Elizaveta Chabanova,Matilda Dale,Federico De Masi,Cecilia Engel Thomas,Kristine H. Allin,Tue H. Hansen,Alison Heggie,Mun-Gwan Hong,Petra J. M. Elders,Gwen Kennedy,Tarja Kokkola,Helle Krogh Pedersen,Anubha Mahajan,Donna McEvoy,Francois Pattou,Violeta Raverdy,Ragna S. Haussler,Sapna Sharma,Henrik S. Thomsen,Jagadish Vangipurapu,Henrik Vestergaard,Leen M. 't Hart,Jerzy Adamski,Petra B. Musholt,Soren Brage,Soren Brunak,Emmanouil Dermitzakis,Gary Frost,Torben Hansen,Markku Laakso,Oluf Pedersen,Martin Ridderstrale,Hartmut Ruetten,Andrew T. Hattersley,Mark Walker,Joline W. J. Beulens,Andrea Mari,Jochen M. Schwenk,Ramneek Gupta,Mark I. McCarthy,Ewan R. Pearson,Jimmy D. Bell,Imre Pavo,Paul W. Franks

PLOS MEDICINE（2020）

引用46浏览0WOS引用

Whole Blood Co-Expression Modules Associate with Metabolic Traits and Type 2 Diabetes: an IMI-DIRECT Study

Gudmundsdottir Valborg,Pedersen Helle Krogh, University of Copenhagen,Artati Anna, University Medical Center Utrecht,Banasik Karina,Brorsson Caroline,Cederberg Henna,Chabanova Elizaveta,De Masi Federico,Elders Petra J.,Forgie Ian,Giordano Giuseppe N., Helmholtz Zentrum München and Technische Universität München, Novo Nordisk Research Centre Oxford,Haid Mark, University of Southern Denmark, Slagelse Hospital,Hattersley Andrew T.,Heggie Alison,Hong Mun-Gwan,Jones Angus G., University of Oxford, Churchill Hospital,Kokkola Tarja,Laakso Markku,Løngreen Peter,Mahajan Anubha,Mari Andrea,McDonald Timothy J.,McEvoy Donna,Musholt Petra B.,Pavo Imre,Prehn Cornelia,Ruetten Hartmut, Novo Nordisk AS,Rutters Femke, Institute of Epidemiology, Helmholtz Zentrum München, Amsterdam Public Health Institute, Amsterdam UMC, Syed Ali,Tajes Juan Fernandez,Thomas Cecilia Engel,Vangipurapu Jagadish, Bornholms Hospital, Swiss Institute of Bioinformatics,Wesolowska-Andersen Agata,Walker Mark, National University of Singapore,Schwenk Jochen M., Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital,Pearson Ewan, Umeå University,Pedersen Oluf

Genome medicine（2020）

引用8浏览0WOS引用

Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study

Naeimeh Atabaki-Pasdar,Mattias Ohlsson,Ana Viñuela,Francesca Frau,Hugo Pomares-Millan,Mark Haid,Angus G Jones,E Louise Thomas,Robert W Koivula,Azra Kurbasic,Pascal M Mutie,Hugo Fitipaldi,Juan Fernandez,Adem Y Dawed,Giuseppe N Giordano,Ian M Forgie,Timothy J McDonald,Femke Rutters,Henna Cederberg,Elizaveta Chabanova,Matilda Dale,Federico De Masi,Cecilia Engel Thomas,Kristine H Allin,Tue H Hansen,Alison Heggie,Mun-Gwan Hong,Petra JM Elders,Gwen Kennedy,Tarja Kokkola,Helle Krogh Pedersen,Anubha Mahajan,Donna McEvoy,Francois Pattou,Violeta Raverdy,Ragna S Häussler,Sapna Sharma,Henrik S Thomsen,Jagadish Vangipurapu,Henrik Vestergaard,Leen M ‘t Hart,Jerzy Adamski,Petra B Musholt,Soren Brage,Søren Brunak,Emmanouil Dermitzakis,Gary Frost,Torben Hansen,Markku Laakso,Oluf Pedersen,Martin Ridderstråle,Hartmut Ruetten,Andrew T Hattersley,Mark Walker,Joline WJ Beulens,Andrea Mari,Jochen M Schwenk,Ramneek Gupta,Mark I McCarthy,Ewan R Pearson,Jimmy D Bell,Imre Pavo,Paul W Franks

medRxiv (2020)

引用0浏览0引用

Processes Underlying Glycemic Deterioration in Type 2 Diabetes: an IMI DIRECT Study

Diabetes Care (2020): 511-518

引用17浏览0WOS引用

University of Dundee Processes Underlying Glycemic Deterioration in Type 2 Diabetes IMI DIRECT Consortium; Bizzotto, Roberto; Jennison, Christopher; Jones, Angus G.; Kurbasic,

semanticscholar（2020）

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Endocrinology and Diabetes

Mark Walker,Alison Heggie,Andrew M. Schaefer,Gráinne S. Gorman

Cambridge University Press eBookspp.154-162, (2018)

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