The Randolph Lab studies the immunobiology of critical illness in children with a focus on life-threatening and fatal infections and acute lung injury. Our long-term goal is to identify new diagnostic tests and therapies that could restore health more rapidly and decrease morbidity and mortality. Our laboratory focuses on clinical-translational research in the areas of the immune response of pediatric patients with acute respiratory distress syndrome and/or overwhelming sepsis, and on identifying genomic pathways that influence disease susceptibility and/or severity. Dr. Randolph founded the Pediatric Acute Lung Injury and Sepsis Investigator’s Network in 2002 and was the Chair for its first 8 years. PALISI is a voluntary clinical-translational research consortium that now includes 80 pediatric intensive care units across the U.S. and Canada.