PROGETTO 1
This project is based on the High Mobility Group A (HMGA). They are nonhistone chromatin proteins that alter chromatin structure and, thereby, regulate the transcription of several genes by either enhancing or suppressing theactivity of transcription factors. This protein family is implicated, through different mechanisms, in both benign and malignant neoplasias. Rearrangements of HMGA genes are a feature of most benign human mesenchymal tumors. Conversely, unrearranged HMGA overexpression is a feature of malignant tumors and is also causally related to neoplastic cell transformation. In our project we will investigate the mechanisms by which the HMGA genes contribute to arcinogenesis.