Professor Koenig's research interest is atherosclerosis, focusing on the identification and evaluation of new biomarkers for cardiometabolic diseases, the clinical pharmacology of cardiovascular compounds, and the clinical epidemiology of cardiovascular disorders. He serves on the steering committee of multiple large, international clinical trials. He has published more than 900 papers and has an H-Index of 101. In 2014 he was given the Rudolf Schönheimer Award from the German Atherosclerosis Society, in 2019 he received the degree of Adjunct Professor from the Medical University of Vienna and in 2020 he was awarded the Paul Morawitz prize from the German Cardiac Society.