基本信息
views: 1
Career Trajectory
Bio
Dr. Cote’s research concentrates on the mitochondrial toxicity of drugs, primarily antiretroviral drugs used in HIV therapy. HIV combination therapy has significantly decreased mortality in the HIV infected population. However, treatment is life-long and as HIV infected individuals survive longer, the toxicity of the drugs and the serious side effects associated can cause of morbidity, non-adherence to prescribed therapy and mortality. HIV drugs can increase mitochondrial DNA (mtDNA) depletion/mutation/deletion through pressure on polymerase gamma, the enzyme responsible for mtDNA replication. In addition, some HIV drugs can inhibit telomerase, the enzyme complex elongating telomeric DNA. MtDNA damage and telomere shortening have been associated with diseases and aging.
Research Interests
Papers共 184 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
HIV MEDICINEno. 2 (2024): 254-261
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMESno. 2 (2024): 197-206
FRONTIERS IN MICROBIOLOGY (2024): 1282291-1282291
Guy Hajj-Boutros,Andrea Faust,John Muscedere,Perry Kim,Naji Abumrad,Stephanie Chevalier,Mylene Aubertin-Leheudre,Howard Bergman,Dawn Bowdish, Jessica Burford,Stacy Carrington-Lawrence,Helene Cote,David E. Dawe,Philipe de Souto Barreto, Colin Farrelly, Robert Fowler,Gilles Gouspillou, Lea Harrington,Sofie Lautrup,Susan Howlett,Mahdi Imani,James Kirkland,George Kuchel,Frederick A. Mallette,Jose A. Morais,John C. Newman,Daryl Pullman,Felipe Sierra, Jeremy Van Raamsdonk,Jennifer Watt,Rebecca Jane Rylett,Gustavo Duque
The journals of gerontology Series A, Biological sciences and medical sciences (2024)
Virusesno. 5 (2024): 755
AIDS (London, England)no. 6 (2023): 995-997
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGYno. 2 (2023): S771-S772
CANADIAN JOURNAL OF BEHAVIOURAL SCIENCE-REVUE CANADIENNE DES SCIENCES DU COMPORTEMENTno. 3 (2023): 240-252
Load More
Author Statistics
#Papers: 180
#Citation: 5095
H-Index: 36
G-Index: 67
Sociability: 7
Diversity: 3
Activity: 28
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn