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Bio
The focus of my laboratory is to improve understanding of how the immune system contributes to Chronic Obstructive Pulmonary Disease (COPD) progression. We are particularly interested in the role of natural killer (NK) cells in COPD pathogenesis and understanding the mechanisms by which these cells could be contributing to lung destruction. We were the first to show that human lung NK cells rapidly killed autologous epithelial lung cells without additional stimulation and that this cytotoxicity was increased in subjects with COPD. In order to address more mechanistic questions, we have begun to incorporate a mouse model of cigarette smoke (CS)-induced lung injury. My recently-funded Merit Award from the VA will focus on the mechanism(s) that leads to increased cytotoxicity of NK cells in COPD. Specifically, we will test the hypothesis that lung dendritic cells (DC) are delivering priming signals to NK cells, which leads to increased cytotoxicity. Additional goals for this project include identifying the DC subset responsible for priming NK cells and determining the mechanism of priming. My laboratory will also begin to investigate the cross-talk between DCs and airway epithelial cells. DCs can directly sense the environment via pattern recognition receptors, but the epithelium may be necessary to activate DCs to certain exposures, including diesel exhaust and fine dust. It is well-established that the asthmatic epithelium centrally influences the function of DCs, which then initiate and maintain allergic T cell responses. Surprisingly, little is known about epithelial cell and DC interactions in COPD and, more specifically, whether these interactions are needed for DC-mediated NK priming. In order to address this question, my lab is establishing air-liquid interface cultures of human airway epithelial cells from subjects with and without COPD. We will use this model to test the effect on DCs and their downstream ability to prime NK cells.
Research Interests
Papers共 76 篇Author StatisticsCo-AuthorSimilar Experts
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Katarina M DiLillo, Lisa Ruvuna,Katherine A Pratte, Karina A Serban,Wassim W Labaki,MeiLan K Han,Christine M Freeman,Russell P Bowler, Jeffrey L Curtis,Kelly B Arnold, SPIROMICS and COPDGene investigators
American journal of respiratory and critical care medicine (2024)
Jintao Xu,Rylan Hissong, Rachel Bareis, Arianna Creech,Kristie D. Goughenour,Christine M. Freeman,Michal A. Olszewski
MBIOno. 3 (2024): e0285323-e0285323
William Z. Zhang,Michelle C. Rice,Katherine L. Hoffman,Clara Oromendia,Igor Z. Barjaktarevic,J. Michael Wells,Annette T. Hastie,Wassim W. Labaki,Christopher B. Cooper,Alejandro P. Comellas,Gerard J. Criner,Jerry A. Krishnan,Robert Paine,Nadia N. Hansel,Russell P. Bowler,R. Graham Barr,Stephen P. Peters,Prescott G. Woodruff,Jeffrey L. Curtis,Meilan K. Han,Karla Ballman,Fernando J. Martinez,Augustine M. K. Choi,Kiichi Nakahira,Suzanne M. Cloonan,Mary E. Choi,Neil E. Alexis,Wayne H. Anderson,Mehrdad Arjomandi,Igor Barjaktarevic,Lori A. Bateman,Surya P. Bhatt,Eugene R. Bleecker,Richard C. Boucher,Stephanie A. Christenson,David J. Couper,Ronald G. Crystal,Claire M. Doerschuk,Mark T. Dransfield,Brad Drummond,Christine M. Freeman,Craig Galban,Eric A. Hoffman,Yvonne Huang,Robert J. Kaner,Richard E. Kanner,Eric C. Kleerup,Lisa M. LaVange,Stephen C. Lazarus,Deborah A. Meyers,Wendy C. Moore,John D. Newell,Laura Paulin,Cheryl Pirozzi,Nirupama Putcha,Elizabeth C. Oelsner,Wanda K. O'Neal,Victor E. Ortega,Sanjeev Raman,Stephen Rennard,Donald P. Tashkin,Robert A. Wise
Trends in immunology (2024)
Jeffrey L Curtis,Lori A Bateman,Susan Murray,David J Couper,Wassim W Labaki,Christine M Freeman,Kelly B Arnold,Stephanie A Christenson,Neil E Alexis, Mehmet Kesimer,Richard C Boucher,Robert J Kaner, Igor Barjaktarevic, Christopher B Cooper,Eric A Hoffman,R Graham Barr,Eugene R Bleecker,Russell P Bowler,Alejandro Comellas,Mark T Dransfield, Michael B Freedman, Nadia N Hansel,Jerry A Krishnan,Nathaniel Marchetti, Deborah A Meyers,Jill Ohar, Wanda K O'Neal,Victor E Ortega, Robert Paine Iii, Stephen P Peters,Benjamin M Smith, Jadwiga A Wedzicha, J Michael Wells,Prescott G Woodruff,MeiLan K Han,Fernando J Martinez
Chronic obstructive pulmonary diseases (Miami, Fla)no. 5 (2024): 444-459
Katarina M. DiLillo,Katy C. Norman,Christine M. Freeman,Stephanie A. Christenson,Neil E. Alexis,Wayne H. Anderson,Igor Z. Barjaktarevic,R. Graham Barr,Alejandro P. Comellas,Eugene R. Bleecker,Richard C. Boucher,David J. Couper,Gerard J. Criner,Claire M. Doerschuk,J. Michael Wells,MeiLan K. Han,Eric A. Hoffman,Nadia N. Hansel,Annette T. Hastie,Robert J. Kaner,Jerry A. Krishnan,Wassim W. Labaki,Fernando J. Martinez,Deborah A. Meyers,Wanda K. O'Neal,Victor E. Ortega,Robert Paine, Stephen P. Peters,Prescott G. Woodruff,Christopher B. Cooper,Russell P. Bowler, Jeffrey L. Curtis,Kelly B. Arnold
Scientific Reportsno. 1 (2023): 1-14
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINEno. 2 (2023): 121-123
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINEno. 3 (2023): 247-255
American journal of respiratory and critical care medicineno. 2 (2023): 121-123
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Author Statistics
#Papers: 75
#Citation: 4206
H-Index: 30
G-Index: 60
Sociability: 6
Diversity: 3
Activity: 14
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