基本信息
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Bio
My laboratory elucidates mechanisms by which cellular machines regulate membrane trafficking. We employ a truly multidisciplinary approach that combines genetic screens and live imaging in the roundworm, Caenorhabditis elegans, with protein biochemistry and structural biology. We recently discovered that a conserved class of membrane-associated proteins initiate endocytosis by converting the AP2 clathrin adaptor complex to an active conformation. Currently, we are working out how another class of highly conserved proteins are acting as negative regulators of the endocytic machinery. Ongoing projects will identify additional mediators of endocytosis and determine their function at the molecular, cellular and organismal levels. Our long-term goal is to understand how the endocytic machinery influences the form and function of multicellular systems such as tissues and organs. We also aim to expand our repertoire of structural biology approaches via collaborations within the department.
Research Interests
Papers共 49 篇Author StatisticsCo-AuthorSimilar Experts
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Erika Beyrent, Derek T Wei,Gwendolyn M Beacham,Sangwoo Park,Jian Zheng,Matthew J Paszek,Gunther Hollopeter
Molecular biology of the cellno. 10 (2024): ar127-ar127
Proceedings of the National Academy of Sciences of the United States of Americano. 38 (2024): e2415313121-e2415313121
biorxiv(2024)
EMPIAR dataset (2023)
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EMPIAR dataset (2023)
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EMPIAR dataset (2023)
crossref(2022)
Gwendolyn M. Beacham, Derek T. Wei, Erika Beyrent, Ying Zhang,Jian Zheng, Mari M. K. Camacho,Laurence Florens,Gunther Hollopeter
bioRxiv (Cold Spring Harbor Laboratory) (2022)
crossref(2022)
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Author Statistics
#Papers: 49
#Citation: 8176
H-Index: 23
G-Index: 49
Sociability: 5
Diversity: 0
Activity: 0
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