Her research encompasses the development and application of statistical methodologies that facilitate quantitative analysis of variation in physiologic processes as well as their application in longitudinal cohort studies. As Director of the Center for Midlife Science (formerly Center for Integrated Approaches to Complex Diseases), she provides stewardship for both the SWAN and the Michigan Bone Health and Metabolism Study (MBHMS) longitudinal cohort data and fosters research opportunities for junior faculty associated with this Center. She has chaired 25 dissertations, mentored numerous junior faculty at UM and other research institutions and has over 150 peer-reviewed publications.