基本信息
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Bio
The overall goal of the research in Professor Nelson's laboratory is to understand the control of smooth muscle and endothelial cell function by ion channels and calcium signaling.
There are three major research areas in the lab:
To understand the mechanisms by which computationally active neurons in the brain control local cerebral blood flow (CBF) ("neurovascular coupling"), using optical techniques to measure calcium signaling and arteriolar diameter in the neurovascular unit (neurons, astrocytes, arteriolar smooth muscle and endothelium) in brain slices as well as CBF in vivo, electrophysiological techniques to measure membrane currents and membrane potential of astrocytes, smooth muscle and endothelial cells from parenchymal arterioles. Arteriolar diameter is also measured in isolated pressurized parenchymal arterioles.
To understand how sympathetic nerves, smooth muscle cells and endothelial cells communicate ("vascular crosstalk") to control the function of resistance-sized peripheral arteries.
To understand the roles of ion channels and calcium signaling in the control of urinary bladder function in health and disease.
Research Interests
Papers共 583 篇Author StatisticsCo-AuthorSimilar Experts
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Thomas J Heppner, Hannah J Fallon, Jason L Rengo, Elleanor M Beaulieu,Grant W Hennig,Mark T Nelson,Gerald M Herrera
American journal of physiology. Regulatory, integrative and comparative physiologyno. 1 (2024): R97-R108
Physiologyno. S1 (2024)
Biophysical Journal (2024)
Nicolas Dupré, Florian Gueniot,Valérie Domenga-Denier, Virginie Dubosclard, Christelle Nilles,David Hill-Eubanks, Christelle Morgenthaler-Roth,Mark T Nelson,Céline Keime, Lydia Danglot,Anne Joutel
The Journal of clinical investigationno. 8 (2024)
Amreen Mughal,Adrian M. Sackheim,Masayo Koide, Grace Bonson, Grace Ebner,Grant Hennig,Warren Lockette,Mark T. Nelson,Kalev Freeman
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISMno. 5 (2024): 680-688
PHYSIOLOGYno. S1 (2023)
PHYSIOLOGYno. S1 (2023)
Jade L Taylor,Katy R Walsh,Ioana-Emilia Mosneag,Thea G E Danby, Nadim Luka, Bishal Chanda,Ingo Schiessl, Ross A Dunne,David Hill-Eubanks,Grant W Hennig,Stuart M Allan,Mark T Nelson,
Proceedings of the National Academy of Sciences of the United States of Americano. 33 (2023)
PHYSIOLOGYno. S1 (2023)
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