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个人简介
Martin's major research focus involved using genetic approaches to elucidate the pathobiology of aging and age-related diseases. Martin's work provided important insights into multiple topics in the field of geroscience. His group conducted genetic linking studies identifying loci associated with familial forms of Alzheimer's disease, a discovery that led to the recognition of amyloid beta (Aβ) in the pathology of that disorder. Martin's group separately identified the genetic defect causing the aging disease Werner syndrome, and its underlying contributory mechanisms to the disorder. His studies provided the first evidence that epithelial cells from arteries, especially from parts that develop severe atherosclerosis, have limited potential to divide. He and colleagues demonstrated that senescent cells cannot be returned to a replicative state when their cytoplasm is combined with cytoplasm from normal, young cells. Martin's laboratory was the first to demonstrate the accumulation of somatic mutations in human epithelial cells during the aging process. His later research used genetic engineering in mice to elucidate mechanisms of aging and Alzheimer's disease.
研究兴趣
论文共 470 篇作者统计合作学者相似作者
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Vipawee S. Chat,Christoph T. Ellebrecht,Paige Kingston,George Gondo,Stacie Bell,Kelly M. Cordoro,Seemal R. Desai,Kristina C. Duffin,Steven R. Feldman,Amit Garg,Joel M. Gelfand,Dafna Gladman,Lawrence J. Green,Johann Gudjonsson,George Han,Jason E. Hawkes,Leon Kircik,John Koo,Richard Langley,Mark Lebwohl,G. Michael Lewitt,Wilson Liao,George Martin,Ana-Maria Orbai,Soumya M. Reddy, Veronica Richardson,Christopher T. Ritchlin,Sergio Schwartzman,Evan L. Siegel,Abby S. Van Voorhees,Elizabeth B. Wallace,Jeffrey M. Weinberg,Kevin L. Winthrop,Paul Yamauchi,April W. Armstrong
Journal of the American Academy of Dermatology (2024)
Journal of Dermatology for Physician Assistantsno. 2 (2023)
Margaret Bobonich,Joe Gorelick,Lakshi Aldredge,Matthew J Bruno, Douglas DiRuggiero,George Martin,Anna M Tallman,Linda Stein Gold
Human molecular genetics online/Human molecular geneticsno. 11 (2023): 1826-1835
Dermatological Reviewsno. 6 (2022): 353-353
Folawiyo Babalola,Cameron Moattari,Brian Berman,Neal Bhatia,Leonard Goldberg, Alice Gottlieb,Ayman Grada,C. William Hanke,Jared Jagdeo,Xochitl Jimenez,Nellie Konnikov,George Martin,Edward Maytin, Michael Milane,Mark Nestor, Aliene Noda,Ted Rosen, Sana Shah,Andrea Willey, Jane Yoo,Nathalie Zeitouni,Daniel Siegel
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作者统计
#Papers: 471
#Citation: 28616
H-Index: 78
G-Index: 160
Sociability: 7
Diversity: 1
Activity: 1
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