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Proteins are becoming increasingly important as therapeutic agents. Due to their inherent instability, proteins present a unique challenge in the development of stable formulations. We study the mechanisms by which proteins are damaged in liquid and dried formulations, and the mechanisms by which additives inhibit this damage. Our work on protein aggregation includes not only studies on therapeutic proteins, but also investigations into the amyloid fibril formation by proteins involved in human diseases such as systemic amyloidosis and Parkinson's disease. In addition, we are studying the use of high hydrostatic pressure to disaggregate and refold proteins.
Research Interest
Development and testing of advanced analytical instruments for particle characterization
Effects of end-user handling and mishandling on quality of therapeutic protein products
Mechanisms for protein degradation and stabilization in pharmaceutical formulations
Research Interests
Papers共 114 篇Author StatisticsCo-AuthorSimilar Experts
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Journal of pharmaceutical sciencesno. 12 (2022): 3261-3274
Theodule Jean-Baptiste,John F. Carpenter,Kevin Dahl, Wellington Derameau, Rosemela Veillard, John Redford Jacquet, Pierre Ludens Osselyn,Albert Figueras
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Author Statistics
#Papers: 115
#Citation: 11089
H-Index: 58
G-Index: 105
Sociability: 6
Diversity: 2
Activity: 4
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