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个人简介
Research in the Kon lab has focused on exploring connections between chronic kidney disease (CKD) and cardiovascular disease (CVD) especially on mechanisms underlying CKD-associated dysfunction in macrophage lipid handling and inflammatory function. This field has gained urgency because of strong epidemiologic evidence that individuals with any degree of renal dysfunction are at a tremendously increased risk for developing CVD. Our studies have established that even in the absence of long-standing CKD and concomitant risk factors, CKD in childhood causes specific lipoprotein abnormalities linked to maintenance of normal vascular function, including inflammatory responses in macrophages and production of adhesion molecules by endothelial cells. In more recent studies, we show that that kidneys are involved in lipoprotein homeostasis and that kidney disease modifies lipoprotein structure, composition, and function which in turn modulate cells in the renal parenchyma. We are especially interested in the role of renal lymphatic vessels which transport lipoproteins out of the interstitial compartment, and we propose are key mediators of the renal response to injury. The laboratory utilizes molecular approach, cellular physiology techniques, and genetically modified mouse models as well as rat models of renal injury to understand how lymphatic vessels affect kidney disease.
研究兴趣
论文共 226 篇作者统计合作学者相似作者
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Claude F Albritton,Mert Demirci,Kit Neikirk,Lale A Ertuglu,Jeanne A Ishimwe, Ashley L Mutchler,Quanhu Sheng,Cheryl L Laffer,Celestine N Wanjalla, Taseer Ahmed,Alexandria Porcia Haynes,Mohammad Saleem,Heather K Beasley,Andrea G Marshall,Zer Vue,Alp T Ikizler,Thomas R Kleyman,Valentina Kon,Antentor Hinton,Annet Kirabo
bioRxiv : the preprint server for biology (2024)
Springer eBookspp.361-376, (2023)
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Journal of the American Society of Nephrologyno. 11S (2023): 765-765
Journal of visualized experiments : JoVE (2023)
Journal of the American Society of Nephrologyno. 11S (2023): 355-355
Circulation researchno. 4 (2023): 350-352
Circulation researchno. 9 (2023): 1226-1245
Advances in kidney disease and healthno. 2 (2023): 124-136
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作者统计
#Papers: 229
#Citation: 8337
H-Index: 52
G-Index: 88
Sociability: 6
Diversity: 0
Activity: 1
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