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个人简介
Dr. Mark Roth is a biochemist and cell biologist who studies “metabolic flexibility,” or how organisms like hibernating bears and squirrels can enter and exit dormant states. The goal of his work is to learn how to turn animals “off,” inducing a state of reversible suspended animation, which could protect against damage caused by extreme conditions. Dr. Roth discovered that certain compounds, such as hydrogen selenide, can be used to induce reversible dormancy, in which breathing and heart rate slow to a near standstill. His work using the related molecule iodide to treat heart attack in several preclinical models has been used in a multicenter Phase 2 trial in Europe and the US conducted by a company he founded: Faraday Pharmaceuticals. A pivotal Phase 3 is currently planned. In 2007 he received a MacArthur Fellowship, or “genius award,” for his research in suspended animation and in 2010 he delivered a TED talk about this work.
研究兴趣
论文共 59 篇作者统计合作学者相似作者
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Jason N. Pitt, Eduardo Chavez, Kathryn M. Provencher,Michelle Chen, Christina Tran,Jennifer Tran,Karen Huang,Anuj Vaid, Marian L Abadir, Naheed Arang,Scott F. Leiser,Mark B. Roth,
biorxiv(2022)
Michael L Morrison,Akiko Iwata, Merry L Wick, Emily VandenEkart,Michael A Insko,Daniel J Henning,Carla Frare,Sarah A Rice,Kelly L Drew,Ronald V Maier,Mark B Roth
Critical care explorationsno. 10 (2020): e0215-e0215
C Anton Fries, Sharon D Lawson,Lin C Wang,Jerry R Spencer,Mark Roth,Rory F Rickard,Vijay S Gorantla, Michael R Davis
Michael L Morrison,Akiko Iwata, Christopher C Keyes, Will Langston,Michael A Insko,Lorrie A Langdale,Mark B Roth
George Edward Black,Kyle K Sokol,Donald M Moe,Jon D Simmons, David Muscat,Victor Pastukh,Gina Capley,Olena Gorodnya,Mykhaylo Ruchko,Mark B Roth,Mark Gillespie, Matthew J Martin
George E Black,Kyle K Sokol,Robert R Shawhan,Matthew J Eckert,Shashikumar Salgar,Shannon T Marko,Zachary S Hoffer, Christopher C Keyes,Mark B Roth, Matthew J Martin
George E. Black,Kyle K. Sokol,Robert R. Shawhan,Matthew J. Eckert,Shashikumar Salgar,Shannon T. Marko,Zachary S. Hoffer, Christopher C. Keyes,Mark B. Roth, Matthew J. Martin
Journal of Trauma and Acute Care Surgeryno. 6 (2016): 1003-1011
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