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His research interests include study of evolution, phylogenomics, and molecular epidemiology of tuberculosis; phylogeography of Mycobacterium tuberculosis and co-evolution with humans; molecular mechanisms and genotypic detection of drug resistance. His current projects focus on the application of next-generation sequencing for genome-wide analysis to understand the pathogenetic characteristics and evolutionary trajectory of various M. tuberculosis lineages and emerging clones.
Dr Mokrousov made a recognized contribution to the study of human-M. tuberculosis coevolution and put forward a hypothesis that evolutionary histories of H. sapiens and human pathogens are comirrored and coshaped. He proposed a new simple measure of genetic distance between geographic populations within a microbial species based on the observed difference in the frequencies of its genotypes. The particular feature regarding current dissemination of tuberculosis is that ordinary human exchange per se is not enough to expose and introduce new strains into an indigenous population, even in the present time of urbanization and overcrowding. It appears that there is a kind of human resistance developed in the local population through its co-existence with historically established clones, acting against newly imported clones. His contribution to evolutionary studies of M. tuberculosis was a development of concept of large-scale phylogenetic sublineages within major genotypes in this species, marked with different evolutionary trajectories and drug resistance capacities. His more recent studies focused on pathogenomic features of the emerging, potentially pandemic clones of Mycobacterium tuberculosis.
Research Interests
Papers共 262 篇Author StatisticsCo-AuthorSimilar Experts
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Edson Machado,Sidra Vasconcellos, Lia Gomes,Marcos Catanho, Jesus Ramos, Luciana de Carvalho,Telma Goldenberg, Margareth Dalcolmo,Paulo Redner,Paulo Caldas, Carlos Campos,Maria Cristina Lourenço,
biorxiv(2024)
A. A. Vyazovaya, I. V. Kostyukova,A. A. Gerasimova, D. R. Terentieva,O. A. Pasechnik,I. V. Mokrousov
Microbiologyno. 2 (2024): 240-242
Phylogenomicspp.323-343, (2024)
Molecular Phylogenetics and Evolution (2024): 108045-108045
Acta biomedica scientificano. 2 (2023): 263-271
Frontiers in cellular and infection microbiology (2023): 1161905
RESPIROLOGY (2023): 49-49
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MICROBIOLOGY SPECTRUMno. 5 (2023)
Diagnostics (Basel, Switzerland)no. 4 (2023): 771-771
RESPIROLOGY (2023): 248-249
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