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个人简介
DNA double-strand break repair and cell cycle checkpoints in mammalian cells
Gross chromosomal arrangements (GCRs) are hall markers of cancer cells, and DNA double-stand breaks (DSBs) are the major cause of cancer-associated genome instability. Unrepaired DSBs can lead to chromosomal breakage and cell death, while incorrectly repaired DSBs would lead to genome instability. The research interest of my laboratory is to understand the molecular mechanisms underlying the function of DNA damage checkpoint and DSB repair to maintain genome stability and prevent cancer and aging. We have established novel EGFP-based DSB repair assays and chromosomal translocation mouse models to investigate the mechanisms underlying DSB repair and chromosomal rearrangement. We are also interested in understanding the role of the breast cancer suppressor BRCA1, and other disease-linked and genome-stability maintenance genes, such as Nbs1, Mre11 and CtIP, in the maintenance of genome stability.
研究兴趣
论文共 44 篇作者统计合作学者相似作者
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Nucleic acids researchno. 3 (2023): 1120-1135
Yuqin Zhao,Kaiping Hou,Youhang Li,Shuailin Hao,Yu Liu, Yinan Na, Chao Li, Jian Cui,Xingzhi Xu,Xiaohua Wu,Hailong Wang
Nucleic acids researchno. 22 (2023): 12207-12223
The Journal of biological chemistryno. 1 (2023): 102770-102770
Cancersno. 10 (2019): 1467-1467
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作者统计
#Papers: 44
#Citation: 3603
H-Index: 27
G-Index: 39
Sociability: 5
Diversity: 2
Activity: 27
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