Michael’s research group has played a central role in the identification of the genetic mutations underlying a number of human facial malformation syndromes including Treacher Collins syndrome, Papillon-Lefevre syndrome, Van der Woude/popliteal pterygium syndrome, amelogenesis imperfecta, and dentine dysplasia. This research is funded by major grants from Wellcome Trust, the Medical Research Council and the National Institute for Dental and Craniofacial Research, USA.