My main research interest is in the genetics of deafness, with a focus on using genetics as a tool to understand the molecular pathways underlying progressive (age-related) hearing loss. My group works with both mouse and human data, using the mouse for understanding the different pathophysiological mechanisms underlying hearing loss and human data to establish the most common types of deafness in the population. Several of the pathways we have identified in the mouse are good targets for drug development to stop the progression of hearing loss and are relevant to human deafness. In addition to running my research group, I am Academic Head of Biological Services. I was awarded the Brain Prize for my research in 2012, and serve as an elected member of Council of the Royal Society.