Dr. Misztal main research is in genetic evaluation methodology and computational strategies that improve livestock production and sustainability. He pioneered single-step GBLUP - a method to consider genomic, pedigree and phenotypic information jointly; this method
become the standard in the field. He also pioneered a novel method to evaluate animals for heat tolerance using special models with data from public weather stations. Software programs developed by his lab have been used by researchers in at least 50 countries and have become the backbone for the genetic evaluation programs of some of the largest animal genetics companies and breed associations in the world.