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个人简介
Dr. Koob also is one of the world’s authorities on the neurobiology of drug addiction. He has contributed to our understanding of the neurocircuitry associated with the acute reinforcing effects of drugs of abuse and more recently on the neuroadaptations of these reward circuits associated with the transition to dependence. He has validated key animal models for dependence associated with drugs of abuse and has begun to explore a key role of anti-reward systems in the development of dependence. The identification of specific neurochemical systems within the basal forebrain system of the extended amygdala involved in motivation has significant theoretical and heuristic impact. From a theoretical perspective, identification of a role for dopaminergic, opioidergic, GABAergic, glutamatergic and corticotropin-releasing factor systems in the excessive drug taking provides a neuropharmacologic basis for the allostatic changes hypothesized to drive the process of pathology associated with addiction, anxiety, and depression. From a heuristic perspective, these findings provide a framework for further molecular, cellular and neurocircuit research that will identify the basis for individual differences in vulnerability to pathology.
研究兴趣
论文共 898 篇作者统计合作学者相似作者
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Tasman’s Psychiatrypp.725-775, (2024)
Renata Marchette, Emma Frye,Lyndsay Hastings,Erika Carlson,Leandro Vendruscolo, Hugo Tejeda,George Koob
Drug and Alcohol Dependence (2024): 110211
Nutrientsno. 10 (2024): 1527
Annual review of pharmacology and toxicologyno. 1 (2024): 255-275
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2024): 173694-173694
Drug and Alcohol Dependence (2024): 110808
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2024): 255-275
Nora D. Volkow,Joshua A. Gordon,Diana W. Bianchi, Michael F. Chiang,Janine A. Clayton, William M. Klein,George F. Koob,Walter J. Koroshetz,Eliseo J. Pérez-Stable, Jane M. Simoni,Bruce J. Tromberg, Richard P. Woychik, Rebecca Hommer, Erica L. Spotts, Benjamin Xu, Julia L. Zehr, Katherine M. Cole,Gayathri J. Dowling, Michelle P. Freund, Katia D. Howlett
Developmental cognitive neuroscience (2024): 101423-101423
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作者统计
#Papers: 912
#Citation: 97923
H-Index: 158
G-Index: 289
Sociability: 8
Diversity: 0
Activity: 4
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