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The research conducted by Michael Shuler focuses on applying chemical reaction engineering principles to biological systems. As part of this work, his research group has developed a new approach to model individual cells mathematically. These models have proven to be important conceptual tools used to test hypotheses about cellular mechanisms. His original model was the first to treat the cell as a reactor and to incorporate a quantitative model of cellular metabolism related directly to changes in the concentrations of nutrients in the external medium.
Another project combines mathematical models of subcellular and cellular mechanisms with whole-animal models as a means to relate the rapidly increasing insight from molecular toxicology and pharmacology with human and animal physiology. The organs of mathematical models are compared with physical models that use living cells to mimic organs such as the liver, colon, GI tract, and lung. These devices are constructed on a microscale using the techniques of nanotechnology and are known as "Body-on-a-Chip" devices. Shuler was the first to demonstrate the feasibility of such systems which are now under worldwide development and commercialization.
研究兴趣
论文共 250 篇作者统计合作学者相似作者
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TAXOL®pp.71-96, (2021)
Lab on a Chipno. 15 (2019): 2619-2619
Christopher W. McAleer,Amy Pointon,Christopher J. Long, Rocky L. Brighton, Benjamin D. Wilkin,L. Richard Bridges, Narasimham Narasimhan Sriram,Kristin Fabre,Robin McDougall,Victorine P. Muse,Jerome T. Mettetal,Abhishek Srivastava,Dominic Williams,Mark T. Schnepper, Jeff L. Roles,Michael L. Shuler,James J. Hickman,Lorna Ewart
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作者统计
#Papers: 253
#Citation: 14196
H-Index: 57
G-Index: 112
Sociability: 6
Diversity: 3
Activity: 24
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