基本信息
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个人简介
His research is focused on protein structure determination from sparse and noisy experimental data. By combining ideas from protein structure prediction with data-guided conformational sampling, we may uniquely determine a protein’s structure to atomic accuracy in cases where neither data nor prediction alone is sufficient. The methods Frank has developed include tools for solving difficult molecular replacement problems, elucidating more than a dozen structures previously unsolved in the laboratories of expert crystallographers. He has also developed a new approach for low-resolution crystal refinement; this method outperforms state-of-the-art refinement packages, making it possible to infer detailed atomic interactions from low-resolution crystal data. Frank is further interested in developing tools for de novo structure determination from low-resolution data, as well as extending these approaches to other sources of data. Additionally, he is more generally interested in structure prediction, developing methods for improving conformational sampling, protein forcefield development, and modeling (and design) of symmetric protein assemblies. Improvements to structure prediction - both sampling methods and forcefields - are critical to designing proteins with novel function.
研究兴趣
论文共 278 篇作者统计合作学者相似作者
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Science (New York, N.Y.)no. 6693 (2024): eadl2528-eadl2528
Qinqin Zhao,Savannah Bertolli,Young-Jun Park,Yongjun Tan,Kevin J Cutler,Pooja Srinivas,Kyle L Asfahl, Citlali Fonesca-García,Larry A Gallagher,Yaqiao Li,Yaxi Wang,Devin Coleman-Derr,
Natureno. 8010 (2024): 165-173
Nature Methodsno. 1 (2024): 117-121
PLOS COMPUTATIONAL BIOLOGYno. 6 (2024): e1011895-e1011895
Journal of Molecular Biologypp.168546-168546, (2024)
Frontiers in pharmacology (2024): 1411428-1411428
NATURE NANOTECHNOLOGYpp.1-6, (2024)
Nature methodsno. 7 (2024): 1340-1348
NATURE METHODSno. 1 (2024)
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作者统计
#Papers: 277
#Citation: 21057
H-Index: 67
G-Index: 144
Sociability: 7
Diversity: 0
Activity: 3
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