基本信息
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Career Trajectory
Bio
Dr. Jaiswal's lab focuses on understanding the biology of the aging hematopoietic system. As a post-doctoral fellow, he identified a common, pre-malignant state for blood cancers by reanalysis of large sequencing datasets. This condition, termed "clonal hematopoiesis", is characterized by the presence of stem cell clones harboring certain somatic mutations, primarily in genes involved in epigenetic regulation of hematopoiesis. Clonal hematopoiesis is prevalent in the aging population and increases the risk of not only blood cancer, but also cardiovascular disease and overall mortality. Understanding the biology of these mutations and how they contribute to the development of cancer and other age-related diseases is the current focus of work in the lab. These studies utilize genetic and clinical information from large population-based cohorts to understand the impact of clonal hematopoiesis in humans. The effect of the mutations causing clonal hematopoiesis is also studied in human and mouse tissues through a combination of genomic profiling, functional assays, and mouse models of disease.
Research Interests
Papers共 105 篇Author StatisticsCo-AuthorSimilar Experts
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Jeongmin Park,GangPyo Ryu,Daniel Nachun, Maggie Maurer,Siddhartha Jaiswal,Dong-Yeop Shin,Ja Min Byun,Junshik Hong,Youngil Koh,Sung-Soo Yoon
Cancer researchno. 6_Supplement (2024): 2277-2277
Yash Pershad,Taralynn Mack,Hannah Poisner,Yasminka A. Jakubek,Adrienne M. Stilp,Braxton D. Mitchell,Joshua P. Lewis,Eric Boerwinkle,Ruth J. F. Loos,Nathalie Chami,Zhe Wang,Kathleen Barnes,Nathan Pankratz,Myriam Fornage,Susan Redline,Bruce M. Psaty,Joshua C. Bis,Ali Shojaie,Edwin K. Silverman,Michael H. Cho,Jeong H. Yun,Dawn DeMeo,Daniel Levy,Andrew D. Johnson,Rasika A. Mathias,Margaret A. Taub,Donna Arnett,Kari E. North,Laura M. Raffield,April P. Carson,Margaret F. Doyle,Stephen S. Rich,Jerome I. Rotter,Xiuqing Guo,Nancy J. Cox,Dan M. Roden,Nora Franceschini,Pinkal Desai,Alex P. Reiner,Paul L. Auer,Paul A. Scheet,Siddhartha Jaiswal,Joshua S. Weinstock,Alexander G. Bick
Nature Communicationsno. 1 (2024): 1-10
Art Schuermans,Caitlyn Vlasschaert,Victor Nauffal,So Mi Jemma Cho,Md Mesbah Uddin,Tetsushi Nakao,Abhishek Niroula,Marcus D. R. Klarqvist,Lachelle D. Weeks,Amy E. Lin,Seyedmohammad Saadatagah,Kim Lannery,Megan Wong,Whitney Hornsby,Steven A. Lubitz,Christie Ballantyne,Siddhartha Jaiswal,Peter Libby,Benjamin L. Ebert,Alexander G. Bick,Patrick T. Ellinor,Pradeep Natarajan,Michael C. Honigberg
European heart journalno. 10 (2024): 791-805
Kurtis M Anthony,Jason M Collins,Shelly-Ann M Love,James D Stewart,Sophie F Buchheit,Rahul Gondalia,Gary G Schwartz,David Y Huang,Jaymie R Meliker,Zhenzhen Zhang,Ana Barac,Pinkal Desai,Kathleen M Hayden,Michael C Honigberg,Siddhartha Jaiswal,Pradeep Natarajan,Alexander G Bick,Charles Kooperberg,JoAnn E Manson,Alexander P Reiner,Eric A Whitsel
Neurologyno. 2 (2024): e208055-e208055
European heart journalno. 10 (2024): 778-790
Taralynn M Mack,Michael A Raddatz,Yash Pershad,Daniel C Nachun,Kent D Taylor,Xiuqing Guo,Alan R Shuldiner,Jeffrey R O'Connell,Eimear E Kenny,Ruth J F Loos,Susan Redline,Brian E Cade,Bruce M Psaty,Joshua C Bis,Jennifer A Brody,Edwin K Silverman,Jeong H Yun,Michael H Cho,Dawn L DeMeo,Daniel Levy,Andrew D Johnson,Rasika A Mathias,Lisa R Yanek,Susan R Heckbert,Nicholas L Smith,Kerri L Wiggins,Laura M Raffield,April P Carson,Jerome I Rotter,Stephen S Rich,Ani W Manichaikul,C Charles Gu,Yii-Der Ida Chen,Wen-Jane Lee,M Benjamin Shoemaker,Dan M Roden,Charles Kooperberg,Paul L Auer,Pinkal Desai,Thomas W Blackwell,Albert V Smith,Alexander P Reiner,Siddhartha Jaiswal,Joshua S Weinstock,Alexander G Bick
Nature Agingpp.1-10, (2024)
Christopher Maximilian Arends,Siddhartha Jaiswal
International Journal of Hematologypp.1-9, (2024)
Zhi Yu,Amélie Vromman,Ngoc Quynh Nguyen,Shamsudheen Karuthedath Vellarikkal,Md Mesbah Uddin,Abhishek Niroula,Gabriel K. Griffin,Michael C. Honigberg,Amy Lin,Christopher J. Gibson,Daniel H. Katz,Usman A. Tahir,Sara Haidermota,Santhi K. Ganesh, T Antoine,Joshua S Weinstock,Thomas R. Austin,Ramachandran S. Vasan,Gina M. Peloso,Whitney E. Hornsby,Patricia A. Ganz,Jo Ann E. Manson,Bernhard Haring,Charles Kooperberg,Alexander P. Reiner,Joshua C. Bis,Bruce M. Psaty,Yuan-I Min,Adolfo Correa,Leslie A. Lange,Wendy S. Post,Jerome I. Rotter,Stephen S. Rich,James G. Wilson,Benjamin L. Ebert,Bing Yu,Christie M. Ballantyne,Josef Coresh,Vijay G. Sankaran,Alexander G. Bick,Siddhartha Jaiswal,Peter Libby,Robert E. Gerszten,Rajat M. Gupta,Pradeep Natarajan
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Esra D. Gumuser,Art Schuermans,So Mi Jemma Cho, Zachary A. Sporn,Md Mesbah Uddin,Kaavya Paruchuri,Tetsushi Nakao, Zhi Yu, Sara Haidermota,Whitney Hornsby, Lachelle D. Weeks,Abhishek Niroula,Siddhartha Jaiswal,Peter Libby,Benjamin L. Ebert, Alexander G. Bick,Pradeep Natarajan,Michael C. Honigberg
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGYno. 20 (2023): 1996-2009
Bloodno. 18 (2023): 2214-2223
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Author Statistics
#Papers: 104
#Citation: 18297
H-Index: 31
G-Index: 73
Sociability: 7
Diversity: 3
Activity: 110
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