William Denney - Institute for Medicine and Engineering;Department of Chemical and Biomolecular Engineering;University of Pennsylvania;Institute for Medicine and Engineering, University of Pennsylvania

基本信息

Career Trajectory

Bio

I am interested in improving efficiency of clinical development of novel therapeutics. My typical research areas are in the fields of pharmacometrics and clinical pharmacology.

Research Interests

Papers共 58 篇Author StatisticsCo-AuthorSimilar Experts

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Pharmacokinetics and Pharmacodynamics Across Infusion Rates of Intravenously Administered Nipocalimab: Results of a Phase 1, Placebo-Controlled Study

Jocelyn H. Leu,An Vermeulen, Claudia Abbes,Santiago Arroyo,William S. Denney,Leona E. Ling

FRONTIERS IN NEUROSCIENCE（2024）

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The Live Biotherapeutic SYNB1353 Decreases Plasma Methionine Via Directed Degradation in Animal Models and Healthy Volunteers

Mylene Perreault,Jillian Means, Erik Gerson,Michael James,Sean Cotton,Christopher G. Bergeron, Mark Simon, Dylan Alexander Carlin, Nathan Schmidt, Theodore C. Moore, Julie Blasbalg,Neal Sondheimer, Kenneth Ndugga-Kabuye,William S. Denney,Vincent M. Isabella,David Lubkowicz,Aoife Brennan,David L. Hava

Cell Host & Microbe (2024)

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Improved noncompartmental half-life estimation with tobit regression

W. Denney

CLINICAL PHARMACOLOGY & THERAPEUTICS (2024): S31-S31

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IgG and anti-AChR Antibody Reduction Explain Nipocalimab Effect on MG-ADL Score Improvement in Patients with gMG

A. Dosne, R. Faelens,B. Valenzuela, J. Zhou, Y. Xiong,J. Leu, Y. Zhu,M. Samtani, A. Vermeulen, L. Ling,S. Ramchandren,H. Sun,W. Denney, J. Perez-Ruixo

EUROPEAN JOURNAL OF NEUROLOGY (2023): 355-355

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Population pharmacokinetic/pharmacodynamic (pk/pd) modeling and simulation for tigulixostat, a novel xanthine oxidase inhibitor for the treatment of gout with hyperuricemia

W. Denney, M. Lee, N. Lee, H. Jun, J. Seo, J. Lee

CLINICAL PHARMACOLOGY & THERAPEUTICS (2023): S69-S69

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Efficacy and Safety of a Synthetic Biotic for Treatment of Phenylketonuria: a Phase 2 Clinical Trial

Jerry Vockley,Neal Sondheimer,Marja Puurunen,George A. Diaz,Ilona Ginevic,Dorothy K. Grange,Cary Harding,Hope Northrup,John A. Phillips III,Shawn Searle,Janet A. Thomas,Roberto Zori,William S. Denney,Sharon L. Ernst, Kristina Humphreys,Nicole McWhorter,Caroline Kurtz,Aoife M. Brennan

Nature metabolismno. 10 (2023): 1685-1690

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SYNB8802 Lowers Urinary Oxalate During a Diet-Controlled Study in Patients with Roux-en-Y Gastric Bypass

Caroline B. Kurtz,Alistair Wheeler, Julie B. Blasbalg,William Denney,James Macdougall,Kyle Wood,Aoife M. Brennan

Journal of the American Society of Nephrologyno. 11S (2023): 808-808

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COMPARISON OF PHENYLALANINE ABSORPTION IN HEALTHY VOLUNTEERS AND PKU PATIENTS IN THE SYNPHENY-1 STUDY

Marja Puurunen,William S. Denney,Caroline Kurtz,Aoife M. Brennan

Molecular genetics and metabolism（2022）

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Publisher Correction: Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study (Jul, 10.1038/s42255-021-00430-7, 2021)

Marja K. Puurunen,Jerry Vockley,Shawn L. Searle,Stephanie J. Sacharow,John A. Phillips,William S. Denney,Benjamin D. Goodlett,David A. Wagner,Larry Blankstein,Mary J. Castillo,Mark R. Charbonneau,Vincent M. Isabella,Vasu V. Sethuraman,Richard J. Riese,Caroline B. Kurtz,Aoife M. Brennan

NATURE METABOLISM（2022）

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Safety and Pharmacodynamics of an Engineered E. Coli Nissle for the Treatment of Phenylketonuria: a First-in-human Phase 1/2a Study

Marja K. Puurunen,Jerry Vockley,Shawn L. Searle,Stephanie J. Sacharow,John A. Phillips III,William S. Denney,Benjamin D. Goodlett,David A. Wagner,Larry Blankstein,Mary J. Castillo,Mark R. Charbonneau,Vincent M. Isabella,Vasu V. Sethuraman,Richard J. Riese,Caroline B. Kurtz,Aoife M. Brennan

Nature metabolism（2022）

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