J. A. Loeb received the M.D. and Ph.D. degrees from the University of Chicago, Chicago, IL. He is currently a Professor in the Department of Neurology and the Associate Director of The Center for Molecular Medicine and Genetics at Wayne State University, Detroit, MI. He subsequently completed a Residency in neurology at the Massachusetts General Hospital, Boston, and a Fellowship Training in epilepsy at Harvard's Beth Israel Hospital. He conducted postdoctoral research at the Department of Neurobiology, Harvard Medical School, with Dr. G. Fischbach where he became interested in how understanding brain development can teach us what goes wrong in human disease and suggest new treatments. He developed a novel way to create biologically targeted protein therapeutics that formed the basis for a biopharmaceutical company he formed in MI called GlyTag. He also directs a project to develop new treatments for human epilepsy through the identification of the genes, molecular and cellular signals that underlie the abnormal electrical activities that characterize this common neurological disorder.