David D Busath

With a focus on molecular biophysics, I have studied voltage-gated ion channel permeation, gramicidin channel perm-selectivity, influenza A M2 proton transport, and chronic pain. In the lab, we have utilized squid giant axon voltage clamping, suspended bilayer voltage clamping, oocyte voltage-clamping, molecular dynamics simulations, monolayer compression, fluorescence anisotropy, atomic force microscopy, neutron reflectance, site-directed mutagenesis, PCR, Sanger sequencing, confocal microscopy, dynamic light-scattering, circular dichroism spectroscopy, membrane protein reconstitution into vesicles, cell culture infections, isothermal titration calorimetry, fMRI, and quantum chemistry simulations. The current focus of the lab is blocking of influenza infections at M2, PB1, and PDGFR.