Kleinfelder is interested in developing exotic applications for digital camera technologies in science, industry and medicine, including high-speed digital video cameras, infrared cameras, x-ray cameras, and large (>100,000,000 pixel) charged-particle sensor arrays.
He currently is creating what promises to be the world's fastest complementary metal oxide semiconductor (CMOS) camera by engineering every pixel to include an analog-to-digital converter and memory. On another front, he is developing a digital camera that integrates a x-ray sensor array on a standard computer chip. An early version of Kleinfelder's x-ray camera will be used to photograph collisions of sub-atomic particles at Brookhaven National Lab. When completed, it will feature 100 million pixels, making it perhaps the world's largest CMOS camera.