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The goal of our lab is to understand the physiological importance of these inter-organelle contacts in specific cellular contexts, including metabolite flux during steady state, and in response to specific triggers, particularly during cell death or cell migration. Using molecular biological and biochemical approaches we will focus on the characterisation of proteins localised at the interface of the mito/ER contacts sites, their potential role in the stability of the MAM structures, and their functions in lipid and calcium fluxes during the execution of the cell death programme. We will couple these techniques with the state-of-the-art advanced microscopic analysis, including spinning disc and scanning confocal systems, super-resolution microscopy, and electron microscopy. To unravel the function of mito/ER contacts sites on cell physiology, live cell imaging will be performed to study organelle movements during cell migration. The precise localisation of target proteins will be studied by the emergent super-resolution microscopy techniques. Finally, we are also interested in understanding the relevance of mitochondrial dynamics and MAMs in the context of mitochondrial disease. We will study the mitochondrial biology, in different cellular models derived from patients, to characterize how mitochondrial morphology and inter-organelle contacts are affected by different gene mutations, and how this contributes to disease progression
研究兴趣
论文共 72 篇作者统计合作学者相似作者
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Brain a journal of neurologyno. 9 (2024): 3189-3203
Cell Death & Diseaseno. 3 (2024): 203-203
Karinder K Brar,Daniel T Hughes, Jordan L Morris, Kelly Subramanian,Shivaani Krishna, Fei Gao, Lara-Sophie Rieder,Sebastian Uhrig, Joshua Freeman, Heather L Smith, Rebekkah Jukes-Jones,Edward Avezov, Jodi Nunnari,Julien Prudent,Adrian J Butcher,Giovanna R Mallucci
Scienceno. 6712 (2024)
Luis Carlos Tábara,Stephen P Burr,Michele Frison,Suvagata R Chowdhury,Vincent Paupe, Yu Nie,Mark Johnson, Jara Villar-Azpillaga, Filipa Viegas,Mayuko Segawa,Hanish Anand,Kasparas Petkevicius,Patrick F Chinnery,Julien Prudent
Cellno. 14 (2024): 3619-3637.e27
Thibaut Vignane,Martín Hugo,Christian Hoffmann,Antionia Katsouda, Jovan Petric,Han Wang,Marko Miler,Ferran Comas,Dunja Petrovic, Suyuan Chen,Jan Lj. Miljkovic,Jordan L Morris,Suvagata Roy Chowdhury,Julien Prudent,Natalija Polovic,Michael P. Murphy,Andreas Papapetropoulos,Dragomir Milovanovic,Milos R. Filipovic
bioRxiv (Cold Spring Harbor Laboratory) (2023)
crossref(2023)
Jan Lj Miljkovic,Nils Burger,Justyna M. Gawel,John F. Mulvey,Abigail A. Norman,Jordan Morris,Takanori Nishimura,Yoshiyuki Tsujihata,Angela Logan,Olga Sauchanka,Stuart T. Caldwell,Tracy A. Prime,Georgina Bates,Dunja Aksentijevic,Hiran Prag,Julien Prudent,Andrew M. James,Thomas Krieg,Richard Hartley, Michael Murphy
Free radical biology & medicine (2023): S132-S133
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#Papers: 70
#Citation: 3253
H-Index: 24
G-Index: 48
Sociability: 6
Diversity: 3
Activity: 120
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