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Our research focuses on the elucidation of the cellular and molecular events by which mutations in genes linked to Parkinson’s disease (PD) contribute to disease pathology. PD has been classically considered a sporadic disease, however, it is now recognized to have a substantial genetic component. Interestingly, the same genes involved in the autosomal-dominantly inherited forms of PD such as SNCA (a-synuclein), and LRRK2 can act as risk factors in sporadic PD, as well. Given the relevance of LRRK2 and a-synuclein with the sporadic forms of PD, our long-term research goal by interrogating a-synuclein and mainly LRRK2-dependent alterations at the cellular, network and behavioral levels is to understand the pathophysiology of PD. The gained knowledge will provide useful insights towards the development of mechanism-based therapeutic opportunities for a disease that is currently addressed symptomatically.
Research Interests
Papers共 40 篇Author StatisticsCo-AuthorSimilar Experts
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Zachary Gaertner, Cameron Oram, Amanda Schneeweis, Elan Schonfeld, Cyril Bolduc,Chuyu Chen,Daniel Dombeck,Loukia Parisiadou, Jean Francois Poulin,Rajeshwar Awatramani
bioRxiv the preprint server for biology (2024)
biorxiv(2024)
Chuyu Chen,Meghan Masotti, Nathaniel Shepard, Vanessa Promes,Giulia Tombesi,Daniel Arango,Claudia Manzoni,Elisa Greggio,Sabine Hilfiker,Yevgenia Kozorovitskiy,Loukia Parisiadou
bioRxiv the preprint server for biology (2024)
Giulia Tombesi, Shiva Kompella,Giulia Favetta,Chuyu Chen,Yibo Zhao,Martina Sevegnani,Antonella Marte,Ilaria Battisti, Ester Morosin,Marta Ornaghi,Lucia Iannotta,Nicoletta Plotegher,Laura Civiero,Franco Onofri,Britta J Eickholt,Giovanni Piccoli,Giorgio Arrigoni,Dayne Beccano-Kelly,Claudia Manzoni,Loukia Parisiadou,Elisa Greggio
biorxiv(2023)
Communications biologyno. 1 (2022): 1211-1211
Tanima De,Honghong Zhang,Cristina Alarcon,Bianca Lec,Juan Avitia,Erin Smithberger,Chuyu Chen,Minnie Horvath, Sara Kwan, Mary Young,Sarbani Adhikari,John Kwon,Jennifer Pacheco,Gail Jarvik,Wei-Qi Wei,Frank Mentch,Hakon Hakonarson,Patrick Sleiman,Adam Gordon,John Harley,Jim Linneman,Scott Hebbring,Loukia Parisiadou,Minoli A. Perera
eLife (2020): 1-30
T. De,H. Zhang,C. Alarcon, B. Lec,J. Avitia,E. Smithberger,Chuyu Chen,M. Horvath, S. Kwan, M. Young,S. Adhikari, J. H. Kwon,J. Pacheco,G.P. Jarvik,W. Wei,F. Mentch,H. Hakonarson,P. Sleiman,A.S. Gordon, J. Harley,J. G. Linneman,S. Hebbring,L. Parisiadou,M. A. Perera
medRxiv (Cold Spring Harbor Laboratory) (2020)
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Author Statistics
#Papers: 40
#Citation: 1699
H-Index: 16
G-Index: 40
Sociability: 6
Diversity: 0
Activity: 0
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