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    • BMC immunology Journal

    Papers
    Multi-HLA Class II Tetramer Analyses of Citrulline-Reactive T Cells and Early Treatment Response in Rheumatoid Arthritis
    Christina Gerstner,Sara Turcinov,Aase H. Hensvold,Karine Chemin,Hannes Uchtenhagen,Tamara H. Ramwadhdoebe,Anatoly Dubnovitsky,Genadiy Kozhukh,Lars Rönnblom,William W. Kwok,Adnane Achour,Anca I. Catrina,
    BMC immunology（2020）SCI 4区
    Background: HLA class II tetramers can be used for ex vivo enumeration and phenotypic characterization of antigen-specific CD4+ T cells. They are increasingly applied in settings like allergy, vaccination and autoimmune diseases. Rheumatoid arthritis (RA) is a chronic autoimmune ...
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    Soluble Cytotoxic T-lymphocyte–associated Antigen 4 (Sctla-4) As a Potential Biomarker for Diagnosis and Evaluation of the Prognosis in Glioma
    Liu Jiajia,Tian Xiaoyi,Wang Yan,Kang Xixiong,Song Wenqi
    BMC immunology（2021）SCI 4区
    Abstract Background The cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is widely considered as a pivotal immune checkpoint molecule to suppress antitumor immunity. However, the significance of soluble CTLA-4 (sCTLA-4) remains unclear in the patients with brain glioma. Here ...
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    Carbon Monoxide Down-Regulates Α4β1 Integrin-Specific Ligand Binding and Cell Adhesion: a Possible Mechanism for Cell Mobilization
    Alexandre Chigaev,Yelena Smagley,Larry A Sklar
    BMC immunology（2014）SCI 4区
    BACKGROUND:Carbon monoxide (CO), a byproduct of heme degradation, is attracting growing attention from the scientific community. At physiological concentrations, CO plays a role as a signal messenger that regulates a number of physiological processes. CO releasing molecules are u...
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    Interleukin-7 Regulates CD127 Expression and Promotes CD8+ T Cell Activity in Patients with Primary Cutaneous Melanoma
    He Hongxia,Qiao Binjun,Guo Shuping,Cui Hongzhou,Zhang Ziyan,Qin Junxia
    BMC immunology（2022）SCI 4区
    BACKGROUND:Interleukin (IL)-7 signaling through CD127 is impaired in lymphocytes in cancers and chronic infections, resulting in CD8+ T cell exhaustion. The mechanisms underlying CD8+ T cell responses to IL-7 in melanoma remain not completely elucidated. We previously showed redu...
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    Reference Ranges of T Lymphocyte Subsets by Single-Platform among Healthy Population in Southwest China
    Wei Bin,Guo Ying,Zhang Liangjun,Zhong Huixiu,Miao Qiang,Yan Lin,Bai Yangjuan,Feng Weihua,Liu Weiping,Niu Qian,Li Yi
    BMC immunology（2021）SCI 4区
    Background Appropriate reference ranges of T lymphocyte subsets are essential for immune status evaluation of patients with immunological diseases. We aim to establish the age- and sex-related reference intervals of T lymphocyte subsets by single-platform for the southwest China ...
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    Active Immunization with Human Interleukin-15 Induces Neutralizing Antibodies in Non-Human Primates
    Yunier Rodríguez-Álvarez,Yanelys Morera-Díaz,Haydee Gerónimo-Pérez,Jorge Castro-Velazco,Rafael Martínez-Castillo,Pedro Puente-Pérez,Vladimir Besada-Pérez,Eugenio Hardy-Rando,Araceli Chico-Capote,Klaudia Martínez-Cordovez,Alicia Santos-Savio
    BMC immunology（2016）SCI 4区
    Background Interleukin-15 is an immunostimulatory cytokine overexpressed in several autoimmune and inflammatory diseases such as Rheumatoid Arthritis, psoriasis and ulcerative colitis; thus, inhibition of IL-15-induced signaling could be clinically beneficial in these disorders. ...
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    Ontology-based Brucella Vaccine Literature Indexing and Systematic Analysis of Gene-Vaccine Association Network
    Junguk Hur,Zuoshuang Xiang,Eva L Feldman,Yongqun He
    BMC immunology（2011）SCI 4区
    BACKGROUND:Vaccine literature indexing is poorly performed in PubMed due to limited hierarchy of Medical Subject Headings (MeSH) annotation in the vaccine field. Vaccine Ontology (VO) is a community-based biomedical ontology that represents various vaccines and their relations. S...
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    Trastuzumab Immunogenicity Development in Patients’ Sera and in Laboratory Animals
    Kilany Lobna Abdel Aziz,Gaber Ayman Abdel Samie, King Salman International University,Zedan Hamdallah Hafez
    BMC immunology（2021）SCI 4区
    Background Immunogenicity is a major challenge in drug development and patient care. Clinicians and regulators are familiar with immunogenicity concerns of monoclonal antibody (mAb) therapeutics, growth factors and enzyme replacements. Although most small therapeutic molecules ar...
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    CTLA4+CD4+CXCR5−FOXP3+ T Cells Associate with Unfavorable Outcome in Patients with Chronic HBV Infection
    Chunhua Wen,Zheyu Dong,Yiyue Wang,Guofu Ye,Yanchen Ma,Xuan Yi,Yang Zhou,Xiaoyi Li,Xinchun Zheng,Jinlin Hou,Yongyin Li,Libo Tang
    BMC immunology（2023）SCI 4区
    Background A major barrier to achieving a favorable outcome of chronic HBV infection is a dysregulated HBV-specific immune response resulting from immunosuppressive features of FOXP3 + T cells. A better definition of FOXP3 + T cells is essential for improving the prognosis of HBV...
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    Analysis of Multivariate Longitudinal Immuno-Epidemiological Data Using a Pairwise Joint Modelling Approach
    London School of Hygiene and Tropical Medicine,Levin Jonathan,Webb Emily L.
    BMC immunology（2021）SCI 4区
    Immuno-epidemiologists are often faced with multivariate outcomes, measured repeatedly over time. Such data are characterised by complex inter- and intra-outcome relationships which must be accounted for during analysis. Scientific questions of interest might include determining ...
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    Adaptive Immune Responses Mediated Age-related Plasmodium Yoelii 17XL and 17XNL Infections in 4 and 8-Week-old BALB/c Mice
    Wuxith Affiliated Hospital of Soochow University,Du Yun-ting,Liu Fei,Sun Xiao-dan,Sun Xun,Chen Guang,Pang Wei,Cao Ya-Ming
    BMC immunology（2021）SCI 4区
    Backgroud: It is important to expound the opposite clinical outcomes between children and adulthood for eradicate malaria. There remains unknown about the correlation between adaptive immune response and age-related in malaria.. Methods: 4 and 8-week-old mice were used to mimic c...
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    Novel Insights in the Regulation of CCL18 Secretion by Monocytes and Dendritic Cells Via Cytokines, Toll-like Receptors and Rheumatoid Synovial Fluid
    Antoine WT van Lieshout,Robbert van der Voort,Linda MP le Blanc,Mieke F Roelofs,B Willem Schreurs,Piet LCM van Riel,Gosse J Adema,Timothy RDJ Radstake
    BMC immunology（2006）SCI 4区
    Background: The T cell attracting chemokine CCL18 is produced by antigen presenting cells and a role for CCL18 has been suggested in the pathogenesis of a variety of diseases. Rheumatoid arthritis (RA) is one of these conditions, in which abundant CCL18 production is present. Alt...
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    Vitamin D and the Vitamin D Receptor Are Critical for Control of the Innate Immune Response to Colonic Injury
    Monica Froicu,Margherita T Cantorna
    BMC immunology（2007）SCI 4区
    BACKGROUND:The active form of vitamin D (1,25(OH)2D3) has been shown to inhibit development of inflammatory bowel disease (IBD) in IL-10 KO mice. Here, the role of the vitamin D receptor (VDR) and 1,25(OH)2D3 in acute experimental IBD was probed.RESULTS:VDR KO mice were extremely...
    Cited303Views0
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    Anti-inflammatory Effect of a Retrovirus-Derived Immunosuppressive Peptide in Mouse Models
    Martin Tolstrup,Claus Johansen,Lars Toft,Finn S Pedersen,Anne Funding,Shervin Bahrami,Lars Iversen,Lars Østergaard,Mogens Duch
    BMC immunology（2013）SCI 4区
    BACKGROUND:Short dimeric or mulitmeric peptides derived from a highly conserved stretch of amino acids from gammaretroviral envelope proteins has been found to have immunosuppressive properties in vitro. Here we test the hypothesis that such immunosuppressive peptides may serve a...
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    Newborn Screening for Sickle Cell Disease in Jamaica: Logistics and Experience with Umbilical Cord Samples
    G. R. Serjeant,B. E. Serjeant,K. P. Mason,R. Gardner,L. Warren,F. Gibson, M. Coombs
    BMC immunology（2016）SCI 4区
    The study aims to describe the logistics and results of a programme for newborn screening for sickle cell disease based on samples from the umbilical cord. Samples were dried on Guthrie cards and analysed by high pressure liquid chromatography. All suspected clinically significan...
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    IFNγ+ Treg In-Vivo and In-Vitro Represent Both Activated Ntreg and Peripherally Induced Atreg and Remain Phenotypically Stable In-Vitro after Removal of the Stimulus
    Volker Daniel,Karina Trojan,Martina Adamek,Gerhard Opelz
    BMC immunology（2015）SCI 4区
    IFNγ-producing CD4+CD25+Foxp3+CD127- Treg represent the first line of Treg during an immune response. In the present study we determined whether IFNγ+ Treg in-vivo and in-vitro are Helios-positive representing activated natural (nTreg) or Helios-negative representing adaptive Tre...
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    Macrophage Migration Inhibitory Factor Urinary Excretion Revisited – MIF a Potent Predictor of the Immunosuppressive Treatment Outcomes in Patients with Proliferative Primary Glomerulonephritis
    Rafał Zwiech
    BMC immunology（2015）SCI 4区
    Macrophage migration inhibitory factor (MIF) is a cytokine that shares many activities with other pro-inflammatory cytokines in primary glomerulonephritis (GN). This study assesses the influence of immunosuppressive treatment on serum and urine MIF in patients with proliferative ...
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    Adverse Events Following Immunization with Pentavalent Vaccine: Experiences of Newly Introduced Vaccine in Iran
    Manoochehr Karami,Pegah Ameri,Jalal Bathaei,Zeinab Berangi,Tahereh Pashaei,Ali Zahiri,Seyed Mohsen Zahraei,Hussein Erfani,Koen Ponnet
    BMC immunology（2017）SCI 4区
    Background: The most important factors that affect the incidence of vaccine-related complications are the constituent biological components of the vaccine, injection site reactions, age and sex. The aim of this study is to determine the incidence rate of adverse events following ...
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    Wnt/β-Catenin Signaling Reduces Bacillus Calmette-Guerin-induced Macrophage Necrosis Through a ROS -Mediated PARP/AIF-dependent Pathway
    Xiaoling Wu,Guangcun Deng,Min Li,Yong Li,Chunyan Ma,Yujiong Wang,Xiaoming Liu
    BMC immunology（2015）SCI 4区
    BACKGROUND:Necrosis of alveolar macrophages following Mycobacterium tuberculosis infection has been demonstrated to play a vital role in the pathogenesis of tuberculosis. Our previous study demonstrated that Wnt/β-catenin signaling was able to promote mycobacteria-infected cell a...
    Cited52Views0
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    Soluble CD14 subtype (sCD14-ST) as biomarker in neonatal early-onset sepsis and late-onset sepsis: a systematic review and meta-analysis
    Iris van Maldeghem,Charlotte M. Nusman,Douwe H. Visser
    BMC immunology（2019）SCI 4区
    Background Early diagnosis of bacterial sepsis in neonates is hampered by non-specific symptoms and the lack of rapid responding laboratory measures. The biomarker soluble CD14 subtype (sCD14-ST) seems promising in the diagnostic process of neonatal sepsis. In order to evaluate t...
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