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    • IUBMB life Journal

    Papers
    Steroid and Thyroid Hormone Receptors in Mitochondria
    Anna-Maria G. Psarra,Constantine E. Sekeris
    IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology（2008）
    Receptors for glucocorticoids, estrogens, androgens, and thyroid hormones have been detected in mitochondria of various cell types by Western blotting, immunofluorescence labeling, confocal microscopy, and immunogold electron microscopy. A role of these receptors in mitochondrial...
    Cited97Views20
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    Search for the “ideal Analgesic” in Pain Treatment by Engineering the Mu‐opioid Receptor
    Pao-Luh Tao,Ping-Yee Law,Horace H. Loh
    IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology（2009）
    The myriad of side effects that associate with morphine has been problematic in the clinical use to manage moderate to severe pain. It has been the holy grail of the pharmacologists to develop a compound, or treatment paradigm that could retain the analgesic effect of the drug as...
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    Opportunities for Protein Interaction Network-Guided Cellular Engineering
    Phillip C. Wright,Stephen Jaffe,Josselin Noirel,Xin Zou
    IUBMB Life（2012）
    As we move further into the postgenomics age where the mountain of systems biology-generated data keeps growing, as does the number of genomes that have been sequenced, we have the exciting opportunity to understand more deeply the biology of important systems, those that are ame...
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    Orexins Facilitates Osteogenic Differentiation of MC3T3‐E1 Cells
    Xuesong Han, Jicheng Zhou,Wei Peng
    IUBMB Life（2018）
    Dysfunction of osteoblastic bone formation and matrix mineralization plays a key role in the pathological development of osteoporosis. The orexin peptide orexin‐A, a highly excitatory neuropeptide hormone, possesses various biological functions by activating its specific G protei...
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    Long Noncoding RNA IGF2AS Regulates High-Glucose Induced Apoptosis in Human Retinal Pigment Epithelial Cells
    Xiaoyi Yu,Yingzi Luo,Gangyi Chen,Hong Liu,Ni Tian,Xiaoting Zen,Qiuhong Liu
    IUBMB Life（2019）
    High-glucose-induced retinal tissue impairment is the major pathological phenotype of diabetic retinopathy. In an in vitro diabetic apoptosis cell model, we evaluated the function of long noncoding RNA, insulin growth factor 2 antisense (IGF2-AS) in high-glucose-injured human ret...
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    GA/GB Fold Switching May Modulate Fatty Acid Transfer from Human Serum Albumin to Bacteria
    Fabio Polticelli,Silvia Caprari,Stefano Gianni,Paolo Ascenzi
    IUBMB Life（2012）
    AbstractHuman serum albumin (HSA) accounts for most of the functions of plasma. Among others, HSA serves as a carrier and a solubilizer for many endogenous and exogenous ligands, including fatty acids (FAs) as well as peptides and proteins such as the GA module of the bacterial p...
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    The Development of Biochemistry and Molecular Biology in China
    You-Shang Zhang
    IUBMB Life（2009）
    Originally, biochemistry or physiological chemistry was a preclinical course in medical schools. At the beginning of the last century, medical schools were established all over China. Among them, one of the best known was Peking Union Medical College (PUMC) founded in 1917 with t...
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    ENSMUST00000147869 Regulates Proliferation and Fibrosis of Mesangial Cells in Diabetic Nephropathy by Interacting with Hspa9
    Min Wang,Xin Chen,Henglu Zhang,Lanlan Li,Yang Xu,Weiping Lu,Yibing Lu
    IUBMB LIFE（2022）
    Our previous study showed that ENSMUST00000147869 was abnormally low expressed in the early stage of diabetic nephropathy (DN). ENSMUST00000147869 could inhibit the fibrosis and proliferation of mouse mesangial cells (MMCs), but the mechanism is still unclear. This study aims to ...
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    Human and Arabidopsis Alpha‐ketoglutarate‐dependent Dioxygenase Homolog Proteins—new Players in Important Regulatory Processes
    Michal Marcinkowski,Tomas Pilzys,Damian Garbicz,Jaroslaw Steciuk,Dorota Zugaj,Damian Mielecki,Tomasz J. Sarnowski,Elzbieta Grzesiuk
    IUBMB Life（2020）
    The family of AlkB homolog (ALKBH) proteins, the homologs of Escherichia coli AlkB 2-oxoglutarate (2OG), and Fe(II)-dependent dioxygenase are involved in a number of important regulatory processes in eukaryotic cells including repair of alkylation lesions in DNA, RNA, and nucleop...
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    Biochemical Properties and Oxalate‐degrading Activity of Oxalate Decarboxylase from Bacillus Subtilis at Neutral Ph
    Carolina Conter,Elisa Oppici,Mirco Dindo,Luigia Rossi,Mauro Magnani,Barbara Cellini
    IUBMB Life（2019）
    Oxalate decarboxylase (OxDC) from Bacillus subtilis is a Mn-dependent hexameric enzyme that converts oxalate to carbon dioxide and formate. OxDC has greatly attracted the interest of the scientific community, mainly due to its biotechnological and medical applications in particul...
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    Novel Therapeutic Regimens for Urethane‐induced Early Lung Cancer in Rats: Combined Cisplatin Nanoparticles with Vitamin‐d3
    Eman Radwan,Maha Ali,Soad M. A. Faied,Hossam M. Omar,Wael S. Mohamed,Sary Kh. Abd-Elghaffar,Ayat A. Sayed
    IUBMB Life（2020）
    Lung cancer remains incurable; therefore, novel therapeutical approaches are of great demand. This study was designed to investigate the effectiveness of cisplatin nanoparticles combined with vitamin-D-3 on urethane-induced early lung cancer in rats and to clarify the underlying ...
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    Partition Chromatography Revisited
    WJ Whelan
    IUBMB Life（2001）
    IUBMB LifeVolume 51, Issue 5 p. 329-330 ArticleFree Access Partition Chromatography Revisited William J. Whelan, William J. WhelanSearch for more papers by this author William J. Whelan, William J. WhelanSearch for more papers by this author First published: 03 January 2008 https...
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    How I Became a Biochemist
    Gerald M. Carlson
    IUBMB Life（2009）
    Recollections of this type tend to be replete with defining moments, profundities, epiphanies, and axioms, usually in Latin. My story, I am afraid, is more a cumulation of small, prosaic, incremental steps leading to the present. I was instructed to focus on my formative stages, ...
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    E. C. (bill) Slater: an Appreciation
    William J. (Bill) Whelan
    IUBMB Life（2016）
    E. C. (Bill) Slater died in March 2016, at the age of 99. Australian by birth, he spent most of his life in Europe. He is survived by his wife Marion, who celebrated her 100th birthday in May. This is a personal account of the life and times that Bill and I shared together, over ...
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    S1p Prophylaxis Mitigates Acute Hypobaric Hypoxia-Induced Molecular, Biochemical, and Metabolic Disturbances: A Preclinical Report
    Sonam Chawla,Babita Rahar,Shweta Saxena
    IUBMB Life（2016）
    Sphingosine-1-phosphate (S1P) is emerging to have hypoxic preconditioning potential in various preclinical studies. The study aims to evaluate the preclinical preconditioning efficacy of exogenously administered S1P against acute hypobaric hypoxia (HH)-induced pathological distur...
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    PGC‐1α Activation As a Therapeutic Approach in Mitochondrial Disease
    Tina Wenz
    IUBMB LIFE（2009）
    Mitochondria play a central role in cellular homeostasis. Hence, mitochondrial dysfunction resulting in impaired ATP supply is detrimental to cell viability and causes severe and often fatal disorders. Current treatment of these mitochondrial disorders is limited and mostly addre...
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    A review of starch-branching enzymes and their role in amylopectin biosynthesis
    Ian J Tetlow,Michael J Emes
    Iubmb Life（2014）
    Starch-branching enzymes (SBEs) are one of the four major enzyme classes involved in starch biosynthesis in plants and algae, and their activities play a crucial role in determining the structure and physical properties of starch granules. SBEs generate -1,6-branch linkages in -g...
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    Evolutionary Mitochondrial Biology in Titisee
    Michael W. Gray,Vamsi K. Mootha
    IUBMB Life（2018）
    In the spring of 2017, we had the privilege of organizing and chairing the 115th International Titisee Conference (ITC). Since 1962, these invitation-only conferences, sponsored by the Boehringer Ingelheim Fonds, have been held at Lake Titisee, in the Black Forest of southern Ger...
    Cited63Views9
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    An Antifungal Mechanism of Curcumin Lies in Membrane-Targeted Action Within Candida Albicans
    Wonyoung Lee,Dong Gun Lee
    IUBMB Life（2014）
    The aim of this study is to investigate the antifungal mechanism of curcumin. This polyphenolic compound has been used traditionally in Asia for medicinal, culinary, and other purposes. Although antifungal effect of curcumin has been reported, this is the first study for its mode...
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