Synthesis and Improving Antibacterial Effectiveness of Ag/Co3V2O8 Nanocomposites by Graphene Oxide for Biomedical Applications

Bacterial resistance has emerged as a global challenge, impacting numerous individuals worldwide each year. The conventional antibiotics routinely employed for treatment have witnessed a decline in efficacy, necessitating the exploration of novel antibiotics with heightened effectiveness and minimal side effects. The formidable nature of multidrug-resistant Gram-positive and Gram-negative bacteria poses challenges in conventional medicine. In response, this study focuses on the synthesis of Ag/Co3V2O8 (Ag/CVO) nanocomposites with Graphene Oxide via the hydrothermal technique. The antibacterial properties of these nanoparticles were investigated against three bacterial species—E. coli, S. aureus, and P. aeruginosa—utilizing the Minimum Inhibitory/Bactericidal Concentration (MIC/MBC) method. Results indicate that the nanoparticle structure with the highest graphene oxide content exhibits superior antibacterial activity. In contrast, CVO micropencils lacking silver ions and graphene oxide demonstrate the least antibacterial efficacy. Collectively, the presented samples disrupt the molecular structure of pathogenic bacteria, exerting inhibitory and bactericidal effects.