The Incidence of Gallbladder Carcinoma is Increasing in the Younger U.S. Population: A SEER-based Study

Gallbladder carcinoma (GBC), remains a relatively rare malignancy but still ranks top for the incidence and bottom for the overall prognosis among the biliary tract tumors 1 Roa J.C. García P. Kapoor V.K. Maithel S.K. Javle M. Koshiol J. Gallbladder cancer. Nat Rev Dis Primers. 2022; 8https://doi.org/10.1038/S41572-022-00398-Y Crossref Google Scholar . According to the Global Cancer Statistics 2020, the number of new cases of GBC has reached 115,949, which accounts for 0.6 percent of all cancers and the incidence rate is reported to be decreasing 2 Sung H. Ferlay J. Siegel R.L. et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021; 71: 209-249https://doi.org/10.3322/CAAC.21660 Crossref PubMed Scopus (0) Google Scholar .