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Hyperactive GlcNAc-1-Phosphotransferase (S1S3 PTase) dramatically increases M6P levels on lysosomal enzymes for substantially improved receptor binding and cellular uptake

Michael R. DiGruccio,Kylie Gray,Riley Marcinczyk,Jonathan Roberts,Udayanga Wanninayake,Vaughn Weaver,Shou Liu,Nastry Brignol,Osman Sheikh,Clarissa Booth,Katherine White, Lin Liu,Hung Do,Russell Gotshall

MOLECULAR GENETICS AND METABOLISM（2024）

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