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A CuI6L4 Cage Dynamically Reconfigures to Form Suit[4]anes and Selectively Bind Fluorinated Steroids.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY(2024)

Univ Cambridge

Cited 0|Views11
Abstract
Simple organic ligands can self-assemble with metal ions to generate metal-organic cages, whose cavities bind guests selectively. This binding may enable new methods of chemical separation or sensing, among other useful functions. Here we report the preparation of a CuI6L4 pseudo-octahedral metal-organic cage, the ligands of which self-assemble from simple organic building blocks. Temperature, solvent, and the presence of different guests governed which structure predominated from a dynamic mixture of cage diastereomers with different arrangements of right- or left-handed metal vertices. Dissolution in dimethyl sulfoxide or the binding of tetrahedral guests led to a chiral tetrahedral T-symmetric framework, whereas low temperatures favored the achiral S4-symmetric diastereomer. Tetrahedral guests with long arms were encapsulated to form mechanically bonded suit[4]anes, with guest arms protruding out through host windows. The cage was also observed to bind fluorinated steroids, an important class of drug molecules, but not non-fluorinated steroids, providing the basis for new separation processes.
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Metal-Organic Frameworks
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要点】:本研究报道了一种CuI6L4金属-有机笼的动态重构特性,能够选择性地结合氟化甾体分子,具有新型化学分离或传感应用潜力。

方法】:通过简单的有机构建模块自组装形成伪八面体金属-有机笼,并通过温度、溶剂以及不同客体的存在来调控笼状结构的立体异构体。

实验】:实验中通过在不同条件下(如溶解在二甲亚砜中或结合四面体客体)观察笼状结构的变化,并使用四臂客体形成机械连接的suit[4]anes,同时发现笼状结构能够选择性地结合氟化甾体而非非氟化甾体,实验数据集未在文中明确提及。