Electrochemical Trifluoromethylation/Spirocyclization of N-Benzylacrylamides to Construct Trifluoromethylated 2-Azaspiro[4.5]decanes

An electrochemical trifluoromethylation/spirocyclization of N-benzylacrylamides with CF3SO2Na as the source of trifluoromethyl group has been developed. This approach is carried out in a simple undivided cell at room temperature without relying on metal-reagents and oxidants, which provides a green and efficient route to construct a series of CF3-containing 2- azaspiro[4.5]decanes. Furthermore, the gram-scale synthesis and transformation can be easily performed.