L'Équilibre Périlleux: Mental Stress and Inflammation in Women.

HomeCirculation: Cardiovascular ImagingVol. 17, No. 2L’Équilibre Périlleux: Mental Stress and Inflammation in Women No AccessEditorialRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessEditorialRequest AccessFull TextL’Équilibre Périlleux: Mental Stress and Inflammation in Women Nidaa Mikail and Cathérine Gebhard Nidaa MikailNidaa Mikail https://orcid.org/0000-0003-4896-1428 Department of Nuclear Medicine, University Hospital Zurich, Switzerland (N.M., C.G.). Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland (N.M., C.G.). and Cathérine GebhardCathérine Gebhard Correspondence to: Cathérine Gebhard, MD, PhD, Department of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, Switzerland. Email E-mail Address: [email protected] https://orcid.org/0000-0001-7240-5822 Department of Nuclear Medicine, University Hospital Zurich, Switzerland (N.M., C.G.). Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland (N.M., C.G.). Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Switzerland (C.G.). Originally published20 Feb 2024https://doi.org/10.1161/CIRCIMAGING.124.016525Circulation: Cardiovascular Imaging. 2024;17This article is a commentary on the followingSex Differences in Coronary Inflammation and Atherosclerosis Phenotypes in Response to Imaging Marker of Stress-Related Neural ActivityFootnotesFor Sources of Funding and Disclosures, see page 94.The opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.Correspondence to: Cathérine Gebhard, MD, PhD, Department of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, Switzerland. Email catherine.gebhard@usz.chREFERENCES1. Arora S, Stouffer GA, Kucharska-Newton AM, Qamar A, Vaduganathan M, Pandey A, Porterfield D, Blankstein R, Rosamond WD, Bhatt DL, et al. Twenty year trends and sex differences in young adults hospitalized with acute myocardial infarction.Circulation. 2019; 139:1047–1056. doi: 10.1161/CIRCULATIONAHA.118.037137LinkGoogle Scholar2. Tawakol A, Ishai A, Takx RA, Figueroa AL, Ali A, Kaiser Y, Truong QA, Solomon CJ, Calcagno C, Mani V, et al. Relation between resting amygdalar activity and cardiovascular events: a longitudinal and cohort.Lancet. 2017; 389:834–845. doi: 10.1016/S0140-6736(16)31714-7CrossrefMedlineGoogle Scholar3. Antoniades C, Tousoulis D, Vavlukis M, Fleming I, Duncker DJ, Eringa E, Manfrini O, Antonopoulos AS, Oikonomou E, Padró T, et al. Perivascular adipose tissue as a source of therapeutic targets and clinical biomarkers.Eur Heart J. 2023; 44:3827–3844. doi: 10.1093/eurheartj/ehad484CrossrefMedlineGoogle Scholar4. Dai N, Tang X, Weng X, Cai H, Zhuang J, Yang G, Zhou F, Wu P, Liu B, Duan S, et al. Stress-related neural activity associates with coronary plaque vulnerability and subsequent cardiovascular events.JACC Cardiovasc Imaging. 2023; 16:1404–1415. doi: 10.1016/j.jcmg.2023.04.004CrossrefMedlineGoogle Scholar5. Dai NTX, Weng X, Cai H, Zhuang J, Yang G, Zhou F, Wu P, Liu B, Duan S, et al. Sex differences in coronary inflammation and atherosclerosis phenotypes in response to mental stress.Circ Cardiovasc Imaging. 2024; 17:e016057. doi: 10.1161/CIRCIMAGING.123.016057LinkGoogle Scholar6. Rossi A, Mikail N, Bengs S, Haider A, Treyer V, Buechel RR, Wegener S, Rauen K, Tawakol A, Bairey Merz CN, et al. Heart-brain interactions in cardiac and brain diseases: Why sex matters.Eur Heart J. 2022; 43:3971–3980. doi: 10.1093/eurheartj/ehac061CrossrefMedlineGoogle Scholar7. Haider A, Bengs S, Luu J, Osto E, Siller-Matula JM, Muka T, Gebhard C. Sex and gender in cardiovascular medicine: presentation and outcomes of acute coronary syndrome.Eur Heart J. 2020; 41:1328–1336. doi: 10.1093/eurheartj/ehz898CrossrefMedlineGoogle Scholar8. Cho L, Davis M, Elgendy I, Epps K, Lindley KJ, Mehta PK, Michos ED, Minissian M, Pepine C, Vaccarino V, et al; ACC CVD Womens Committee Members. Summary of updated recommendations for primary prevention of cardiovascular disease in women: JACC state-of-the-art review.J Am Coll Cardiol. 2020; 75:2602–2618. doi: 10.1016/j.jacc.2020.03.060CrossrefMedlineGoogle Scholar9. Vaccarino V, Shah AJ, Rooks C, Ibeanu I, Nye JA, Pimple P, Salerno A, D’Marco L, Karohl C, Bremner JD, et al. Sex differences in mental stress-induced myocardial ischemia in young survivors of an acute myocardial infarction.Psychosom Med. 2014; 76:171–180. doi: 10.1097/PSY.0000000000000045CrossrefMedlineGoogle Scholar10. Fiechter M, Haider A, Bengs S, Maredziak M, Burger IA, Roggo A, Portmann A, Warnock GI, Schade K, Treyer V, et al. Sex differences in the association between inflammation and ischemic heart disease.Thromb Haemost. 2019; 119:1471–1480. doi: 10.1055/s-0039-1692442CrossrefMedlineGoogle Scholar11. Gebhard C, Regitz-Zagrosek V. Colchicine in patients with chronic coronary disease.N Engl J Med. 2021; 384:776–777. doi: 10.1056/NEJMc2034992CrossrefMedlineGoogle Scholar12. Bengs S, Haider A, Warnock GI, Fiechter M, Pargaetzi Y, Rampidis G, Etter D, Wijnen WJ, Portmann A, Osto E, et al. Quantification of perivascular inflammation does not provide incremental prognostic value over myocardial perfusion imaging and calcium scoring.Eur J Nucl Med Mol Imaging. 2021; 48:1806–1812. doi: 10.1007/s00259-020-05106-0CrossrefMedlineGoogle Scholar13. Brotman DJ, Golden SH, Wittstein IS. The cardiovascular toll of stress.Lancet. 2007; 370:1089–1100. doi: 10.1016/S0140-6736(07)61305-1CrossrefMedlineGoogle Scholar14. Li H, Xia N. The role of oxidative stress in cardiovascular disease caused by social isolation and loneliness.Redox Biol. 2020; 37:101585. doi: 10.1016/j.redox.2020.101585CrossrefMedlineGoogle Scholar15. Herman JP, McKlveen JM, Ghosal S, Kopp B, Wulsin A, Makinson R, Scheimann J, Myers B. Regulation of the hypothalamic-pituitary-adrenocortical stress response.Compr Physiol. 2016; 6:603–621. doi: 10.1002/cphy.c150015CrossrefMedlineGoogle Scholar16. Haider A, Bengs S, Maredziak M, Messerli M, Fiechter M, Giannopoulos AA, Treyer V, Schwyzer M, Kamani CH, Patriki D, et al. Heart rate reserve during pharmacological stress is a significant negative predictor of impaired coronary flow reserve in women.Eur J Nucl Med Mol Imaging. 2019; 46:1257–1267. doi: 10.1007/s00259-019-4265-7CrossrefMedlineGoogle Scholar17. Heck AL, Handa RJ. Sex differences in the hypothalamic-pituitary-adrenal axis’ response to stress: an important role for gonadal hormones.Neuropsychopharmacology. 2019; 44:45–58. doi: 10.1038/s41386-018-0167-9CrossrefMedlineGoogle Scholar18. Wenner MM, Greaney JL, Matthews EL, McGinty S, Kaur J, Vongpatanasin W, Fadel PJ. Influence of age and estradiol on sympathetic nerve activity responses to exercise in women.Med Sci Sports Exerc. 2022; 54:408–416. doi: 10.1249/MSS.0000000000002823CrossrefMedlineGoogle Scholar19. Barko K, Paden W, Cahill KM, Seney ML, Logan RW. Sex-specific effects of stress on mood-related gene expression.Mol Neuropsychiatry. 2019; 5:162–175. doi: 10.1159/000499105CrossrefMedlineGoogle Scholar20. Mikail N, Rossi A, Bengs S, Haider A, Stähli BE, Portmann A, Imperiale A, Treyer V, Meisel A, Pazhenkottil AP, et al. Imaging of heart disease in women: review and case presentation.Eur J Nucl Med Mol Imaging. 2022; 50:130–159. doi: 10.1007/s00259-022-05914-6CrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetailsRelated articlesSex Differences in Coronary Inflammation and Atherosclerosis Phenotypes in Response to Imaging Marker of Stress-Related Neural ActivityNeng Dai, et al. Circulation: Cardiovascular Imaging. 2024;17 February 2024Vol 17, Issue 2 Advertisement Article InformationMetrics © 2024 American Heart Association, Inc.https://doi.org/10.1161/CIRCIMAGING.124.016525PMID: 38377232 Originally publishedFebruary 20, 2024 KeywordsEditorialsacute coronary syndromeamygdalacardiovascular diseasespositron emission tomographysex characteristicsPDF download Advertisement SubjectsChronic Ischemic Heart DiseaseComputerized Tomography (CT)Nuclear Cardiology and PETPrognosis