Green synthesis and theoretical study of new 1,3,4‐oxadiazoles: Application of Cu/Fe₃O₄@MWCNT magnetic nanocomposites

Cu/Fe 3 O 4 @MWCNT magnetic nanocomposites (MNCs) as an effective catalyst was promoted producing of novel derivatives of 1,3,4‐oxadiazols in high yields. These new compounds were synthesized by using multicomponent reaction of ninhydrins, diamines or hydroxyamines, ester of acetylene with electron deficient, α‐haloketones, hydrazoyl chloride, and synthesized nanocatalyst in aqueous media. It should be mentioned that the high performance of nanocatalyat was synthesized by using water extract of Petasits hybridus leaves, which was utilized in these reactions for many times to confirm the reusability of nanocatalyst. The antioxidant property of new synthesized 1,3,4‐oxadiazols is owing to having NH group which was evaluated by two procedures named diphenyl‐picrylhydrazine (DPPH) radical trapping and Ferric ions (Fe 3+ ) reducing potential (FRAP) experiment. Also, the antimicrobial activity of new generated 1,3,4‐oxadiazols was evaluated by disk distribution process utilizing two kinds of Gram‐negative bacteria and Gram‐positive bacteria, proving bacterial growth was stopped by using of these compounds. This employed procedure for preparation of 1,3,4‐oxadiazols derivatives conveys benefits including reaction with low time, products with high yields, and possibility of separating catalyst and products using an easy procedure.