What is the Best Chemotherapy Regimen for Uterine Carcinosarcoma?

Uterine carcinosarcoma (UCS) are rare tumors with high aggressive behavior. Chemotherapy is the mainstay of treatment either in the adjuvant and the metastatic setting. Previous carcinogenetic theory considered carcinosarcoma as a biphasic tumor with an epithelial and mesenchymal component and were treated accordingly with drugs directed towards these two components (i.e. cisplatin-ifosfamide). Actually UCS are reclassified as epithelial cancers with metaplastic de-differentiated components and drugs with proven activity in epithelial tumors (i.e. carboplatin-paclitaxel) have been implemented in the treatment algorithm. The paper will review literature evidences in UCS treatment and will support the strategy which identify carboplatin-paclitaxel as the standard of care.