Abstract C056: Prognostic Relevance of SUV420H2 (KMT5C) Gene Expression in Clear Cell Renal Cell Carcinoma: Implications for Patients of African Ancestry

Abstract African Americans are second only to Native Americans in having the highest incidence of renal cancer. Despite this statistic, very few studies have examined whether there are racial/ethnic differences in gene and protein expression. Since higher stage/grade ccRCC is uniformly lethal, it is imperative that candidate genes and their corresponding protein products be found that can identify patients across various demographics who are at greater risk of progressing to advanced stage/grade, drug-resistant clear cell renal carcinoma; and that can point to the drivers of ccRCC progression in different demographic groups. Using KIRC (clear cell renal carcinoma) TCGA dataset, we observed that SUV420H2 (KMT5C), a Lysine N-Methyltransferase, is significantly overexpressed in ccRCC (p<1E-12). Moreover, SUV420H2 transcripts were significantly elevated in higher stages and grades (p Citation Format: Romonia Renee Reams, Simone Heyliger, Marilyn Saulsbury. Prognostic relevance of SUV420H2 (KMT5C) gene expression in clear cell renal cell carcinoma: Implications for patients of African ancestry [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr C056.