The Relationship between Solute Carrier Family 1 Member 1 Polymorphisms (rs301430 and rs301434) and the Risk of Obsessive-Compulsive Disorders: A Meta-Analysis and Trial Sequential Analysis

Background: Obsessive-compulsive disorder (OCD) is a chronic, general, and usually disabling disorder. A family-based study has illustrated that the risk of OCD was related to genetics. This meta-analysis aims to assess the association between solute carrier family 1 member 1 polymorphisms (rs301430 and rs301434) and OCD susceptibility. Methods: The study comprehensively searched various databases without language restrictions, including the Cochrane Library database, PubMed, Embase, Web of Science, CNKI, CBM, VIP, and WanFang Data. The data were obtained before April 1, 2023, and odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were utilized and pooled in the analysis using Stata 17.0 software. Sensitivity analysis was conducted to analyze the robustness and reliability of the results, and Egger's test was used to examine the publication bias. Trial Sequential Analysis (TSA) was performed by TSA 0.9.5.10 Beta software to assess the required information size. Results: Based on the data derived from eight articles with 3932 participants (2147 OCD subjects and 1785 controls), the risk of OCD and its subtypes were observed to be associated with solute carrier family 1 member 1 (SLC1A1) rs301434 polymorphism (overall OCD: G vs. A: OR = 1.19, 95% CI = 1.06-1.34; GG vs. AA: OR = 2.18, 95% CI = 1.36-3.49; GG+GA vs. AA: OR = 1.21, 95% CI = 1.01-1.45; early-onset OCD: G vs. A: OR = 1.19, 95% CI = 1.04-1.37; GG vs. AA: OR = 1.79, 95% CI = 1.03-3.10; late-onset OCD: GG vs. AA: OR = 3.25, 95% CI = 1.36-7.78; GG vs. GA+AA: OR = 3.22, 95% CI = 1.34-7.76; OCD in Asians: G vs. A: OR = 1.20, 95% CI = 1.00-1.44; GG vs. AA: OR = 3.72, 95% CI = 1.61-8.56; GG vs. GA+AA: OR = 3.70, 95% CI = 1.61-8.51). Meanwhile, no association was found between OCD susceptibility and SLC1A1 rs301430 polymorphism. Conclusion: This meta-analysis demonstrates that the SLC1A1 rs310434 may be associated with OCD susceptibility, and more studies are needed to corroborate the conclusions. Systematic Review Registration: PROSPERO: CRD42023426696.