Aza‐Prins Cyclization on Ketones to Access Piperidines with Tetrasubstituted Carbon Stereocenters
Advanced synthesis & catalysis(2023)
Abstract
The aza-Prins cyclization in presence of a variety of aliphatic, aromatic, and heterocyclic ketones is disclosed. The developed method allows an access to diverse C-2 functionalized piperidines, bearing a tetrasubstituted or spiranic carbon stereocenter, in a range of 30 to 87% yields. When diastereomers were formed, the trans isomer was identified as the major product. image
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Key words
Aza-Prins,Ketones,2-Spiropiperidines,Tetrasubstituted Stereocenter,Titanium
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