CD-MOFs: from Preparation to Drug Delivery and Therapeutic Application
Carbohydrate polymers(2024)
摘要
Cyclodextrin metal-organic frameworks (CD-MOFs) show considerable advantages of edibility, degradability, low toxicity, and high drug loading, which have attracted enormous interest, especially in drug delivery. This review summarizes the typical synthesis approaches of CD-MOFs, the drug loading methods, and the mechanism of encapsulation and release. The influence of the structure of CD-MOFs on their drug encapsulation and release is highlighted. Finally, the challenges CD-MOFs face are discussed regarding biosafety assessment systems, stability in aqueous solution, and metal ion effect.
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关键词
Cyclodextrin metal organic frameworks,Synthesis approaches,Drug encapsulation,Drug release,Therapeutic application
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