Structurally Diverse Terpenoids from Elephantopus Scaber L. and Their Acetylcholinesterase Inhibitory Activities.
Phytochemistry(2023)
摘要
Three undescribed compounds elephantopuscabers A-C, along with one previously reported compound spirowallichiione, were isolated from Elephantopus scaber L. Their structures were determined via extensive NMR spectroscopic analysis, quantum chemical calculations, and single-crystal X-ray diffraction crystallography. A plausible biosynthetic pathway for spirowallichiione was proposed. All the isolated compounds were tested for their acetylcholinesterase inhibitory activities. Among them, elephantopuscaber B and C displayed promising inhibitory activities against AChE, and the binding sites were predicted by molecular docking.
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关键词
Elephantopus scaber L.,Asteraceae,Terpenoids,Acetylcholinesterase inhibitor,Molecular docking
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