The Association of Time Interval Between Surgery and Neoadjuvant Chemoradiation Therapy with Pcr and Overall Survival for Locally Advanced Rectal Adenocarcinoma

In the current study, we found that among patients who achieve pCR, OS does not depend on the time interval between the completion of RT and receipt of surgery, while among patients who do not achieve pCR, delaying surgery >12 weeks is associated with reduced OS. An interval of 9-12 weeks was the best optimal time as it was associated with the highest OR of achieving pCR and better OS compared to other interval times.