Mouse Model of Anti-Obesity Effects of Blautia hansenii on Diet-Induced Obesity.

Reportedly, a relationship exists between intestinal microflora and obesity-related lifestyle diseases. spp. a major intestinal microbiota, accounts for 3-11% of human intestinal microflora. Epidemiological reports have described that people with more visceral fat have less in their intestinal tract irrespective of age or gender. However, the effect of oral administration of heat-sterilized on obesity has not been clarified. Therefore, the aim of this study was to evaluate the effects of dietary administration on obesity in high-fat-diet-induced obesity in a mouse model. Heat-sterilized cells of were used. C57BL/6J mice (normal mice, = 7) were fed with each experimental diet for nine weeks. Diets for experimentation were: normal-fat (NF) diets, high-fat (HF) diets, and high-fat + (HF + ) diets. The HF + group was administered about 1 × 10 (CFU/mouse/day) of During the periods of experimentation, body weight, food intake, water consumption, and fecal weight were recorded, and glucose tolerance tests were performed. Subsequently, the white adipose tissue (WAT) weight and serum components were measured. Short-chain fatty acid contents in the feces and cecum were analyzed. Furthermore, changes in the intestinal microflora were analyzed using meta-genomics analysis. Results showed that the total weight of WAT in the HF + group was significantly lower (13.2%) than that of the HF group. Moreover, the HF + group exhibited better glucose tolerance than the HF group. Productivity of short-chain fatty acids in the intestinal tract was at a significantly ( < 0.05) low level in the HF group; on the other hand, it recovered in the HF + group. Furthermore, there was a higher ratio of ( < 0.05) in the intestinal tracts of the HF + group than in the HF group. These results suggest that administration suppresses obesity induced by a high-fat diet.