Assessment of the individual determinants of two fibrinolysis assays, GFC and ECLT in platelet-depleted plasma and derived euglobulin fraction respectively.

•Regulation of fibrinolysis involves a delicate interplay between activators and inhibitors.•Euglobulin fraction is largely depleted in α2-antiplasmin, α2-macroglobulin and TAFI.•Euglobulin fraction shows no PAI-1 activity despite preserved PAI-1 antigen levels.•Only GFC showed a moderate correlation with α2-antiplasmin activity.•GFC could be of interest for the exploration of a fibrinolysis defect, especially in the IVDR EU 2017/746 era.