Expression of EZH2 and H3K27me3 predicts tumor biology of urothelial carcinoma.

Rasheeda Mohamedali,Suvradeep Mitra,Swarnendu Mandal,Prasant Nayak,Amit K Adhya,Suvendu Purkait

Indian journal of pathology & microbiology（2023）

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摘要

This study establishes an important role of the key epigenetic regulators EZH2 and H3K27me3 in the pathobiology of urothelial carcinomas. Strong expression of EZH2 and weak expression of H3K27me3 are associated with higher grade, proliferative index and invasive behavior.

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关键词

Epigenetics,EZH2,urothelial carcinoma

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