Pharmacological effect of gold nanoparticles from red algae Halymenia venusta on A549 cell line

Green synthesis of stable gold nanoparticles (AuNPs) from the red seaweed Halymenia venusta was performed using an environmentally, eco-friendly, and efficacy against lung cancer cell line. The synthesized H. venustamediated gold nanoparticles (H. venusta-AuNPs) were analyzed using various analytical techniques. Ultra Violet spectroscopy (UV) revealed that 510 nm is where H. venusta-AuNP Surface Plasmon Resonance (SPR) peaks. Fourier Transform Infra-red spectroscopy (FTIR) analysis was used to determine the biological components present in the H. venusta-AuNPs. X-ray Diffraction (XRD) spectroscopy was used to ascertain that the H. venustaAuNPs had a crystalline structure. H. venusta-AuNPs were found to be spherical in shape and in size of 81 nm by scanning electron microscopy (SEM). The antimicrobial activity of H. venusta-AuNP was performed against the common microbial pathogens Pseudomonas aeruginosa, Staphylococcus aureus, and Klebsiella pneumonia. The tagging of anti-oxidant-rich components allowed the biogenic H. venusta-AuNPs to exhibit remarkable antioxidant and free radical scavenging capabilities. H. venusta-AuNPs were tested for their anti-cancer effects on lung cancer (A549) cells and showed potential for their cytotoxic and antiproliferative activities, while the ability of H. venusta-AuNPs to cause apoptotic activity in lung cancer cells was validated using the reactive oxygen species (ROS) assay. Present results indicated that synthetic H. venusta-AuNPs had a promising anti-cancer potential.